Thiamine deficiency and cardiovascular disorders

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
E S Eshak, A E Arafa

Abstract

Thiamine, also known as vitamin B1, functions as a cofactor in the metabolism of carbohydrates and amino acids. Thiamine deficiency has been suggested to be associated with many cardiovascular diseases (CVDs) and risk factors including type 1 and type 2 diabetes (T1D and T2D, respectively), obesity, chronic vascular inflammation, dyslipidemia, heart failure (HF), myocardial infarction (MI) and conduction defects, and depression. The aim of this review was to explore the evidence of thiamine deficiency among subjects with CVDs or risk factors, illustrate the theories explaining the thiamine-CVDs associations, and describe the effect of thiamine supplementation. Human and animal studies were collected from various scientific databases following the PRISMA guidelines without limitation regarding the publication year. Studies investigating the prevalence of thiamine deficiency among patients with CVDs and the effect of thiamine supplementation on their conditions were summarized. Thiamine deficiency could have a role in the development of CVDs. Future studies should focus on the impact of thiamine supplementation on reversing CVDs and risk factors associated with its deficiency.

Citations

Apr 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ovidiu MituIrina Iuliana Costache
Nov 14, 2019·International Journal of Molecular Sciences·Natasa CvetinovicJerneja Farkas
Aug 23, 2020·Pharmaceuticals·Georgios EleftheriadisDimitrios Fatouros
Nov 26, 2019·The American Journal of Clinical Nutrition·Bianca VoraKathleen M Giacomini
Sep 17, 2020·Nutrients·Federico PaceiChiara Colombo
Jan 16, 2021·Journal of Diabetes·Sandra Elisa Adami Batista GonçalvesDaniella Cabral de Freitas
May 15, 2021·Clinical Nutrition Research·Ja-Young Seo, Jeong-Hwa Choi
Jun 26, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Josef FinstererFulvio A Scorza
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Justyna PiechockaKrystyna Szymandera-Buszka
Aug 11, 2021·Nutrients·Małgorzata SzczukoLuciano Saso

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