Thiamine deficiency in critically ill patients with sepsis.

Journal of Critical Care
Michael W DonninoLong Ngo

Abstract

The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis. This was a prospective, observational study. The setting was an urban, tertiary care center with approximately 50,000 emergency department visits per year and intensive care units numbering approximately 50 total beds. Thirty study patients admitted with clinical suspicion of infection and evidence of tissue hypoperfusion, as defined by a lactic acid level greater than 4 mmol/L or hypotension (systolic blood pressure <90 mm Hg) requiring vasopressor support, were enrolled. A control group of 30 patients presenting to the emergency department with minor emergencies was also enrolled. There were no interventions. Plasma thiamine levels were measured at 0, 24, 48, 72, and 162 hours for patients in the study group. Absolute TD was defined as less than or equal to 9 nmol/L derived from established abnormal ranges per Quest laboratory. In the study group, 3 (10%) of 30 had absolute TD upon presentation; and an additional 3 patients (6/30, 20%) developed TD within 72 hours. None of the 30 controls (0/30, 0%) exhibited absolute ...Continue Reading

References

Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·D OriotG Huault
Jan 1, 1988·Intensive Care Medicine·A M CruickshankA Shenkin
Jan 1, 1997·Digestion·D LambertJ P Nicolas
Dec 8, 2004·Annals of Internal Medicine·Michael Donnino
Sep 22, 2007·Critical Care Medicine·Mervyn Singer

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Citations

Dec 13, 2012·Transplantation·Moritz SchmelzleSimon C Robson
Feb 7, 2012·BMC Clinical Pharmacology·Howard A SmithlineDavid J Greenblatt
Aug 11, 2011·Critical Care : the Official Journal of the Critical Care Forum·Michael W DonninoPraveen Akuthota
Dec 2, 2011·Critical Care : the Official Journal of the Critical Care Forum·Karin AmreinRudolf E Stauber
May 16, 2014·Journal of Inflammation·José Antenor Araújo de AndradeSérgio da Cunha
Oct 2, 2013·Mayo Clinic Proceedings·Lars W AndersenMichael W Donnino
Sep 3, 2013·Journal of Critical Care·Ari MoskowitzMichael W Donnino
Jan 16, 2016·Critical Care Medicine·Michael W DonninoUNKNOWN Center for Resuscitation Science Research Group
May 20, 2015·Nutrition Journal·George DabarBertrand Jaber
Jan 15, 2014·Journal of Critical Care·Nara Aline CostaMarcos Ferreira Minicucci
May 20, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Evangelia DounousiKostas Katopodis
Mar 24, 2012·Journal of Critical Care·Andrea Freyer DugasMichael W Donnino
Dec 4, 2014·Journal of Critical Care·Daniel O Thomas-RueddelUNKNOWN Medical Education for Sepsis Source Control and Antibiotics Study Group
Nov 13, 2014·Annals of the American Thoracic Society·Katherine M BergMichael W Donnino
Apr 12, 2016·Critical Care Medicine·Catherine S SassoonHamid M Said
Jun 2, 2017·Annals of the American Thoracic Society·Harin PatelCarey C Thomson
Jan 8, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Laura L Frank
Aug 7, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Yong Sing Da SilvaCameron Dezfulian
Aug 13, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·J Scott Baird, Thyyar M Ravindranath
Dec 18, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Marilù GiacaloneFrancesco Forfori
Jan 10, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Krishnan SriramKimberly Joseph
Jul 21, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Amir Y KamelThomas R Ziegler
Mar 14, 2018·Journal of Veterinary Emergency and Critical Care·Patricia G RosensteinDez Hughes
Jul 22, 2016·Journal of Intensive Care Medicine·Wouter van SnippenburgPeter E Spronk
Sep 15, 2018·Critical Care Medicine·Paul E Marik
Jul 22, 2018·Critical Care Medicine·Jordan A WoolumAlexander H Flannery
Oct 13, 2018·Critical Care Medicine·Paul E Marik
Nov 8, 2018·Antioxidants & Redox Signaling·Vera A ReitsemaHjalmar R Bouma
Aug 8, 2018·Laboratory Medicine·Osman EvliyaogluRalf Weiskirchen
Jan 16, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kursat GundoganThomas R Ziegler
Oct 27, 2018·SAGE Open Medicine·Michael Zhang, David F Jativa
Sep 14, 2017·European Journal of Clinical Nutrition·H MaedaT Tanaka
Jul 19, 2019·Journal of Intensive Care Medicine·Farid SadakaJacklyn O'Brien
Sep 5, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Halden F Scott
Sep 14, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·William Manzanares, Gil Hardy
Mar 3, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Joshua S V da SilvaUNKNOWN Parenteral Nutrition Safety and Clinical Practice Committees, American Society for Parenteral and Enteral Nutrition
Apr 23, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Jake T B CollieRinaldo Bellomo
May 29, 2019·Critical Care Nursing Quarterly·Jacob P CountsG Morgan Jones

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