PMID: 2498935Jan 1, 1989Paper

Thiamine deficiency in utero alters response to ethanol in adulthood

Psychopharmacology
P R MartinA B Mukherjee

Abstract

To determine whether prenatal thiamine deficiency, a frequent concomitant of alcoholism, reduces the response to ethanol during adulthood in the rat as does ethanol exposure in utero (Abel et al. 1981), pregnant Sprague-Dawley rats received either control or thiamine deficient diets together with daily injections of the thiamine antagonist pyrithiamine. At 7 months of age, male offspring were exposed to precisely regulated ethanol vapor concentrations in an inhalation chamber for 24 h and blood ethanol concentrations (BECs) and ethanol-induced intoxication were determined. Prenatally thiamine deficient rats and controls were indistinguishable in terms of appearance, body and liver weights, and the ratios of liver to body weight and brain to liver weight. However, total body water was significantly greater, and BECs and behavioral impairment were decreased, in the experimental rats. These findings indicate that prenatal thiamine deprivation is associated with reduced pharmacologic effect of ethanol as a result of increases in its volume of distribution and rate of metabolism.

References

May 11, 1978·The New England Journal of Medicine·S K Clarren, D W Smith
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·P R MartinM J Eckardt
Feb 1, 1988·Alcoholism, Clinical and Experimental Research·B Tabakoff, P L Hoffman
Jan 1, 1986·Alcoholism, Clinical and Experimental Research·R D VinganE P Riley
Jan 1, 1986·Alcoholism, Clinical and Experimental Research·E P RileyR T Hamlin
Mar 15, 1985·Science·P R MartinM J Eckardt
Feb 15, 1985·American Journal of Obstetrics and Gynecology·B RoeckleinA B Mukherjee
Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S W LevinA B Mukherjee
Dec 1, 1980·The American Journal of Clinical Nutrition·A M Hoyumpa
Aug 1, 1984·The Journal of Pediatrics·A O Cavdar
Nov 1, 1984·European Journal of Pediatrics·B Høgh, L Stenhammar
Jul 18, 1980·Science·A P StreissguthD W Smith
Jun 1, 1980·The Journal of Pediatrics·S E ShaywitzB A Shaywitz

❮ Previous
Next ❯

Citations

Aug 7, 2013·Alcoholism, Clinical and Experimental Research·Jennifer L HelferBrian R Christie
Sep 16, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Olena KlossMiyoung Suh
Sep 14, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Vasileios StolakisStylianos Tsakiris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved