Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism

Archives of Biochemistry and Biophysics
Muhammad AfzalFiroz Anwar

Abstract

Present study, was an effort to scrutinize the molecular and biochemical role of ibuprofen and thiamine combination in diethylnitrosamine (DEN)-induced HCC in Wistar rats. Single intraperitoneal injection of DEN (200 mg/kg) was used for induction of HCC in rats. The rats were divided into eight various groups. DEN induced rats were treated with pure ibuprofen (40 mg/kg) and thiamine in combination for the period of 12th weeks. The protocol was terminated after the 16th week. Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz., interlukin-6 (IL-6), Tumor necrosis factor (TNF-α) and Interleukin-1β (IL-1β) with decrease in body weight. Macroscopic evaluation, revealed DEN group rats confirmed the expansion of hepatic nodules, which were reduced by the individual treatment of ibuprofen and thiamine, but the synergistic treatment of ibuprofen and thiamine confirm the significant reduction of hepatic nodules. Further, this combination possesses the significant chemoprotective effect in DEN-induced HCC by restoring the hepatic...Continue Reading

Citations

May 8, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jie PanTing Liu
Feb 9, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Azeza GumaDiana Anderson
Aug 25, 2021·Applied Biochemistry and Biotechnology·Junling LiuMeng Tian
Oct 27, 2021·Journal of Gastrointestinal Cancer·Asmaa I NabeelSarah A Mohamed
Dec 3, 2021·Nutrition and Cancer·José Reginaldo Alves de Queiroz JúniorCarina Scanoni Maia

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