Thiamine (vitamin B1) in septic shock: a targeted therapy.

Journal of Thoracic Disease
Ari Moskowitz, Michael W Donnino

Abstract

Thiamine (vitamin B1) is a water-soluble vitamin essential for human health. Thiamine deficiency is causal and/or contributory in a number of debilitating diseases including beri-beri, the Wernicke-Korsakoff syndrome, optic neuropathy, and others. While thiamine deficiency is relatively rare in developed nations as a result of dietary supplementation, thiamine deficiency is more common in nutritionally compromised populations. Thiamine pyrophosphate, a thiamine derivative, is essential to the citric acid cycle and thiamine deficiency can result in impaired aerobic respiration and cellular energy production. Thiamine also plays an important role in the pentose phosphate pathway and other key metabolic processes. Although thiamine deficiency is a known cause of lactic acidosis, it has been recently evaluated as a potential contributor to refractory lactic acidosis and organ injury in septic shock and other shock states. In this article, we review the epidemiology of thiamine deficiency in septic shock and the existing evidence base supporting thiamine supplementation. We conclude that specific sepsis phenotypes may stand to benefit the most from thiamine supplementation, and efforts might be made to identify and supplement these ...Continue Reading

Citations

Aug 12, 2020·Intensive Care Medicine·Sung Yeon HwangUNKNOWN Korean Shock Society (KoSS)
Nov 4, 2020·Journal of Veterinary Internal Medicine·Diego E GomezDavid L Renaud
Mar 16, 2021·Frontiers in Neurology·Marcus Vinicius Branco de OliveiraMarcus Vinícius Magno Gonçalves
Apr 6, 2021·Brain, Behavior, & Immunity Health·Marcus Vinicius Branco de OliveiraDaniel Galera Bernabé
Apr 27, 2021·American Journal of Physiology. Endocrinology and Metabolism·K M O'ConnorF B McDonald
Jun 24, 2021·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Robert S ReamJeremy S Garrett
Jun 13, 2021·Journal of Critical Care·Yub Raj SedhaiMarkos G Kashiouris
Aug 14, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Adam M DeaneYasmine Ali Abdelhamid
Jun 30, 2021·Acute and Critical Care·Manoj Kumar Reddy SomaguttaObumneme Jude Iloeje
Sep 21, 2021·Seminars in Respiratory and Critical Care Medicine·Jeremy WeinbergerChanu Rhee

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