Thiazide Diuretic-Induced Change in Fasting Plasma Glucose: a Meta-analysis of Randomized Clinical Trials.

Journal of General Internal Medicine
Jill J HallJohn-Michael Gamble

Abstract

Prior meta-analyses measuring thiazide-induced glycemic change have demonstrated an increased risk of incident diabetes; however, this measure's definition has changed over time. To determine the magnitude of change in fasting plasma glucose (FPG) for thiazide diuretics. A research librarian designed and conducted searches in Medline®, EMBASE, and EBM Reviews-Cochrane Central Register of Controlled Trials (inception through July 2018) and International Pharmaceutical Abstracts (inception to December 2014). Randomized, controlled trials comparing a thiazide or thiazide-like diuretic to any comparator reporting FPG were identified. Trials enrolling < 50 participants, those with a follow-up period of < 4 weeks, and conference abstracts were excluded. Independent duplicate screening of citations and full-text articles, data extraction, and assessment of risk of bias was conducted. Ninety-five studies were included (N = 76,608 participants), with thiazides compared with placebo, beta-blockers, calcium channel blockers, renin-angiotensin-aldosterone-system inhibitors, potassium-sparing diuretic, and others alone or in combination. Thiazide diuretics marginally increased FPG (weighted mean difference 0.20 mmol/L (95% CI 0.15-0.25); I2...Continue Reading

References

Aug 9, 1979·The New England Journal of Medicine·UNKNOWN Veterans Administration Cooperative Study Group on Antihypertensive Agents
Feb 26, 1992·JAMA : the Journal of the American Medical Association·D SiegelR Fine
Sep 1, 1989·The Journal of International Medical Research·J HegbrantJ Månsby
May 1, 1986·Clinical Pharmacology and Therapeutics·P Wicker, J Clementy
Nov 1, 1980·The American Journal of Medicine·A Helgeland
May 1, 1995·British Journal of Clinical Pharmacology·R FogariG Villa
Dec 1, 1994·QJM : Monthly Journal of the Association of Physicians·S NielsenC E Mogensen
Dec 5, 1998·Diabetes Care·R P ByingtonJ R Sowers
Sep 27, 2000·Journal of Clinical Epidemiology·D MoherA Liberati
Jul 12, 2002·Statistics in Medicine·P P Glasziou, S L Sanders
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
May 15, 2003·American Journal of Hypertension·Heinrich HolzgreveHans Uwe Janka
Mar 24, 2004·Hypertension·Paolo VerdecchiaCarlo Porcellati
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Roberto FogariAmedeo Mugellini
May 28, 2008·Hypertension·Barry L CarterUNKNOWN Working Group from the National Heart, Lung, and Blood Institute
Nov 5, 2008·Hypertension·Tariq ShafiRulan S Parekh
Dec 9, 2008·International Journal of Cardiology·Kwang Kon KohEak Kyun Shin

❮ Previous
Next ❯

Citations

Apr 16, 2020·MMW Fortschritte der Medizin· Bs
Mar 11, 2021·Postgraduate Medical Journal·Ziying LinBernard M Y Cheung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Steven M Smith
The Australian Nurses' Journal
The New England Journal of Medicine
Tara Cowtan
Annual Review of Medicine
L E EARLEY, J ORLOFF
La Revue du praticien
D DurandJ M Suc
© 2021 Meta ULC. All rights reserved