PMID: 9291881Aug 1, 1997Paper

Thiazide diuretics and the initiation of anti-gout therapy

Journal of Clinical Epidemiology
J H GurwitzJ Avorn


While physiologic and epidemiologic evidence link diuretic therapy with hyperuricemia, no previous study has quantified the risk for initiation of treatment specific for hyperuricemia or gout among elderly patients taking thiazide diuretics. We performed a retrospective cohort study of 9249 enrollees aged 65 or older in the New Jersey Medicaid program who were newly started on an antihypertensive medication from November 1981 through February 1989 and who had no prior use of anti-gout therapy (allopurinol, colchicine, or a uricosutic) during the preceding one-year period. We used Cox proportional hazards analysis to determine the risk for the initiation of anti-gout therapy in patients using various antihypertensive treatment regimens relative to no antihypertensive exposure. Patient follow-up extended for up to two years. Antihypertensive exposure was characterized over the entire period of follow-up according to the following categories: thiazide diuretic therapy alone; non-thiazide antihypertensive therapy; thiazide diuretic therapy in combination with any non-thiazide antihypertensive agent(s); and no antihypertensive use. Antihypertensive exposure was entered into the model as a time-varying covariate. Estimates of risk we...Continue Reading


May 1, 1978·Annals of Internal Medicine·M H Liang, J F Fries
Apr 14, 1990·BMJ : British Medical Journal·J E CarlsenP Johansen
Mar 1, 1987·The American Journal of Medicine·E W CampionL O DeLabry
Jun 29, 1985·British Medical Journal·J Auböck, P Fritsch
Jan 1, 1986·Arthritis and Rheumatism·J Z Singer, S L Wallace
Oct 1, 1969·The American Journal of Medicine·T H Steele, S Oppenheimer
Jan 1, 1967·Pennsylvania Medicine·W T Lampe
Feb 1, 1993·Drugs·V L Star, M C Hochberg
Jan 1, 1993·Journal of Computer Assisted Tomography·M E RuizM D Smith
May 1, 1993·American Journal of Public Health·J H GurwitzJ Avorn

❮ Previous
Next ❯


Jul 27, 2007·Rheumatology International·Francesco De LeonardisFrancesco Trotta
Jun 7, 2013·Aging Clinical and Experimental Research·Francesco BolzettaGiuseppe Sergi
May 25, 2005·Clinics in Geriatric Medicine·Christopher M Wise
Sep 16, 2000·Rheumatic Diseases Clinics of North America·C A Agudelo, C M Wise
Nov 30, 2006·Nature Clinical Practice. Rheumatology·Saima Chohan, Michael A Becker
Feb 3, 2011·Current Opinion in Rheumatology·Jasvinder A SinghJoseph Kundukulam
Nov 18, 2005·Annals of the Rheumatic Diseases·H J E M JanssensA L M Verbeek
Feb 20, 2010·Clinical Interventions in Aging·Mattheus K Reinders, Tim L Th A Jansen
Aug 9, 2002·European Journal of Heart Failure·Lukas E SpiekerGeorg Noll
Jun 12, 2013·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Barbara J Zarowitz, Terrence E O'Shea
Mar 23, 2012·BMC Geriatrics·Robert L JacksonPatricia A MacDonald
Oct 2, 2007·Heart Failure Clinics·Domenic A SicaWilliam H Frishman
Mar 21, 2007·Rheumatic Diseases Clinics of North America·Christopher M Wise
Oct 9, 2007·Journal of the American Academy of Dermatology·Sima HalevyUNKNOWN EuroSCAR Study Group
Jan 23, 2014·Arthritis & Rheumatology·Saskia BrudererChristoph R Meier
Sep 27, 2014·The Journal of Clinical Hypertension·Liza WilsonJoseph J Saseen
Oct 4, 2016·The Journal of Pharmacy and Pharmacology·In-Soo YoonSeung-Sik Cho
Dec 7, 2007·Clinical and Experimental Hypertension : CHE·Dimitris P Papadopoulos, Vasilios Papademetriou
Oct 5, 2013·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Barbara FarrellNafisa Ingar
Mar 27, 2007·The Journal of Urology·Sarah C Huen, David S Goldfarb
Oct 18, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Aylin Altan RiedelAdel G Fam
Mar 19, 2003·Orthopaedic Nursing·Mary Kamienski
Oct 3, 2003·The American Journal of Clinical Nutrition·Li-Ching LyuChing-Lan Chen
Oct 20, 2017·BMC Geriatrics·Christina SommerauerAndreas Sönnichsen
Oct 8, 2015·Drugs & Aging·Thiruvinvamalai S Dharmarajan, Lekshmi Dharmarajan
Nov 13, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Tamara da Silva CunhaIta Pfeferman Heilberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Annals of the Rheumatic Diseases
J T Scott, C S Higgens
The Journal of Rheumatology
John G HanlySander Veldhuyzen van Zanten
Annals of the Rheumatic Diseases
H J E M JanssensA L M Verbeek
© 2021 Meta ULC. All rights reserved