Thiazolidinedione and Metformin Use and the Risk of Benign Prostate Hyperplasia in Veterans with Diabetes Mellitus

Journal of Men's Health
Harvey J MurffMarie R Griffin

Abstract

Chronic inflammation is important in the development of benign prostatic hyperplasia (BPH) and certain oral antidiabetic medications have anti-inflammatory properties. The purpose of this study was to determine if use of thiazolidinediones or metformin was associated with a reduced risk of requiring medical or surgical treatment for BPH compared to sulfonylureas among diabetic men. We constructed a retrospective cohort of 192,457 male veterans newly prescribed either rosiglitazone, pioglitazone, metformin, or a sulfonylurea. We used Cox proportional hazard regression to assess the association between thiazolidinedione or metformin use and the risk of requiring medical or surgical treatment for BPH compared to sulfonylurea use. New BPH treatment was defined by either a new prescription for a α-1 blocker or 5α-reductase inhibitors or a surgical procedure indicated for severe BPH. In 259,995 person-years of follow up we identified 14,690 new treatments for BPH. After adjusting for covariates including age, HbA1c, and body mass index, we found no association between rosiglitazone (adjusted hazard ratio [aHR] 1.02, 95% CI 0.86, 1.20), pioglitazone (aHR 0.79, 95% CI 0.45, 1.38), or metformin use (aHR 0.99, 95% CI 0.94, 1.03) and risk...Continue Reading

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Citations

Apr 19, 2016·Andrology·S La VigneraA E Calogero
Nov 10, 2017·American Journal of Physiology. Renal Physiology·Zongwei Wang, Aria F Olumi
Mar 31, 2016·Cancer Prevention Research·Chen-Pin WangAmelie G Ramirez
Jan 29, 2021·International Neurourology Journal·Min Ho LeeSung Chul Kam
Apr 9, 2021·The World Journal of Men's Health·Chin Hsiao Tseng

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