Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker Fatty rat heart

Diabetes
Robert J SidellKieran Clarke

Abstract

Obesity is associated with risk factors for cardiovascular disease, including insulin resistance, and can lead to cardiac hypertrophy and congestive heart failure. Here, we used the insulin-sensitizing agent rosiglitazone to investigate the cellular mechanisms linking insulin resistance in the obese Zucker rat heart with increased susceptibility to ischemic injury. Rats were treated for 7 or 14 days with 3 mg/kg per os rosiglitazone. Hearts were isolated and perfused before and during insulin stimulation or during 32 min low-flow ischemia at 0.3 ml small middle dot min(-1) small middle dot grams wet wt(-1) and reperfusion. D[2-(3)H]glucose was used as a tracer of glucose uptake, and phosphorus-31 nuclear magnetic resonance spectroscopy was used to follow energetics during ischemia. At 12 months of age, obese rat hearts were insulin resistant with decreased GLUT4 protein expression. During ischemia, glucose uptake was lower and depletion of ATP was greater in obese rat hearts, thereby significantly impairing recovery of contractile function during reperfusion. Rosiglitazone treatment normalized the insulin resistance and restored GLUT4 protein levels in obese rat hearts. Glucose uptake during ischemia was also normalized by rosi...Continue Reading

References

Jan 1, 1992·Life Sciences·D J Paulson, A G Tahiliani
Sep 1, 1991·Journal of Molecular and Cellular Cardiology·S C DennisL H Opie
Jan 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·L D SegelJ S Stern
Jul 1, 1995·Journal of Molecular and Cellular Cardiology·H R CrossG K Radda
Sep 15, 1993·Biochemical and Biophysical Research Communications·F KanaiY Ebina
Sep 1, 1996·Metabolism: Clinical and Experimental·M ShimabukuroN Takasu
Feb 12, 1998·The Journal of Clinical Investigation·C F BurantR A Graves
Jan 23, 1999·The Journal of Clinical Investigation·A DresnerG I Shulman
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y T ZhouR H Unger
Apr 15, 2000·Nature·J M Friedman
Jun 6, 2000·Nature·S KerstenW Wahli
Jul 11, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L H YoungR R Russell
Aug 23, 2000·The Journal of Clinical Investigation·J M Olefsky
Sep 7, 2000·The Journal of Endocrinology·V De Gennaro-ColonnaE E Muller
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·L M KingK Clarke
Feb 24, 2001·Nature·J S Flier
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R RamasamyS R Bergmann

❮ Previous
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Citations

Feb 6, 2008·Cardiovascular Drugs and Therapy·Terje S Larsen, Ellen Aasum
Nov 3, 2006·Nature Reviews. Drug Discovery·Dunstan Cooke, Steve Bloom
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Borja García-BuenoJuan C Leza
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Sunil AsnaniVivian A Fonseca
Feb 11, 2005·Current Opinion in Gastroenterology·Jason S R Jennings, Peter D Howdle
Mar 13, 2008·Diabetes, Obesity & Metabolism·R E Buckingham, A Hanna
Oct 16, 2007·Acta Physiologica·P J H SmeetsM van Bilsen
Jan 13, 2005·Canadian Journal of Physiology and Pharmacology·Quy N DiepErnesto L Schiffrin
Nov 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ya XuGregory G Schwartz
Apr 9, 2008·Physiological Reviews·E Dale AbelGary Sweeney
Mar 3, 2006·The Journal of Clinical Investigation·Liliane Michalik, Walter Wahli
Jun 12, 2012·Journal of Lipid Research·Janice V HuangGregory G Schwartz
Feb 3, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Vi Lier GohFrancisco A Sylvester
Jun 15, 2011·World Journal of Cardiology·Siripong PaleeNipon Chattipakorn
Dec 18, 2013·Journal of Cardiovascular Pharmacology·Zhao V WangJoseph A Hill
Jun 4, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James T ThackerayJean N DaSilva
Jun 5, 2014·Journal of Physiology and Biochemistry·Maher A KamelHanan Abo Elfetooh
Oct 7, 2014·Cardiovascular Drugs and Therapy·Nattayaporn ApaijaiNipon Chattipakorn
Jan 22, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Janice V HuangGregory G Schwartz
Dec 26, 2007·Archives of Physiology and Biochemistry·O-J HowE Aasum
Dec 25, 2003·The Journal of Physiology·Yakhin ShimoniDavid L Severson
Sep 25, 2012·Heart Failure Clinics·Tae-Sik Park, Ira J Goldberg
Feb 17, 2009·Journal of Molecular and Cellular Cardiology·Michael N Sack
Feb 6, 2008·The Veterinary Clinics of North America. Small Animal Practice·Peter Vajdovich
Oct 13, 2007·Journal of Molecular and Cellular Cardiology·Ellen AasumTerje S Larsen
Mar 28, 2007·Heart Failure Clinics·Ronald M Witteles, Michael B Fowler
Sep 9, 2006·Endocrinology and Metabolism Clinics of North America·Gregg C Fonarow, Preethi Srikanthan
Sep 9, 2006·Endocrinology and Metabolism Clinics of North America·Preethi SrikanthanSusan Davis
Jan 30, 2007·Prostaglandins & Other Lipid Mediators·Marcin BaranowskiJan Gorski
Sep 10, 2014·Cardiovascular Diabetology·Ruduwaan SalieAmanda Lochner
Aug 10, 2005·Diabetes/metabolism Research and Reviews·Simona HefetzEleazar Shafrir

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