Thiazolidinediones and fractures: evidence from translating research into action for diabetes.

The Journal of Clinical Endocrinology and Metabolism
Dori BilikWilliam H Herman

Abstract

Thiazolidinedione (TZD) treatment has been associated with fractures. The purpose of this study was to examine the association between TZD treatment and fractures in type 2 diabetic patients. Using data from Translating Research into Action for Diabetes, a multicenter prospective observational study of diabetes care in managed care, we conducted a matched case-control study to assess the odds of TZD exposure in patients with type 2 diabetes with and without fractures. We identified 786 cases based on fractures detected in health plan administrative data. Up to four controls without any fracture diagnoses were matched to each case. Controls were matched on health plan, date of birth within 5 yr, sex, race/ethnicity, and body mass index within 5 kg/m(2). We performed conditional logistic regression for premenopausal and postmenopausal women and men to assess the odds of exposure to potential risk factors for fracture, including medications, self-reported limited mobility, and lower-extremity amputations. We found statistically significant increased odds of exposure to TZDs, glucocorticoids, loop diuretics, and self-reported limited mobility for women 50 yr of age and older with fractures. Exposure to both loop diuretics and TZDs,...Continue Reading

References

Mar 17, 2007·Diabetes Care·Subhashini YaturuSushil K Jain
Jan 29, 2008·Diabetes Care·Steven E KahnUNKNOWN Diabetes Outcome Progression Trial (ADOPT) Study Group
Apr 2, 2008·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN PERISCOPE Investigators
Apr 17, 2008·Archives of Internal Medicine·Lionel S LimUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group
Apr 30, 2008·Archives of Internal Medicine·Christian MeierChristoph R Meier
Jan 28, 2009·Archives of Internal Medicine·Laura D CarboneAndrea Z LaCroix
Apr 17, 2009·Journal of the American Geriatrics Society·Lionel S LimKristine E Ensrud
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·Daniel H SolomonTil Stürmer
Aug 12, 2009·Archives of Internal Medicine·Colin R DormuthJames M Wright
Oct 31, 2009·The Journal of Clinical Endocrinology and Metabolism·Bernard ZinmanUNKNOWN ADOPT Study Group
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Charles H Hennekens, David Demets
Jan 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Zeina A HabibL Keoki Williams

❮ Previous
Next ❯

Citations

Sep 5, 2012·Diabetologia·H M ColhounUNKNOWN Scottish Diabetes Research Network Epidemiology Group
Apr 30, 2013·Current Diabetes Reports·Hanford YauKenneth Cusi
Apr 24, 2013·Drugs & Aging·Kate L LapaneSwapnil Rajpathak
Jan 18, 2012·Nature Reviews. Endocrinology·Christine HamannLorenz C Hofbauer
Oct 7, 2011·Journal of Diabetes Investigation·Kohei Kaku, Mitsuru Hashiramoto
Jun 30, 2012·PPAR Research·Angélica Amorim Amato, Francisco de Assis Rocha Neves
May 28, 2011·Circulation Research·Jordan D MillerDonald D Heistad
Jul 3, 2013·The Journal of Spinal Cord Medicine·Laura D CarboneFrances M Weaver
Jan 1, 2014·Archives of Physical Medicine and Rehabilitation·Laura D CarboneFrances M Weaver
Jan 31, 2014·Endocrine-related Cancer·José O AlemánMonica Girotra
May 8, 2013·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Angela ThompsonJoseph J Saseen
Feb 12, 2014·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Angela M ThompsonJoseph J Saseen
Dec 3, 2011·PPAR Research·Wei Wei, Yihong Wan
Oct 7, 2014·Metabolism: Clinical and Experimental·Anastasia D DedeGeorge Trovas
May 25, 2013·Diabetes Care·UNKNOWN TODAY Study Group
May 27, 2014·Expert Review of Clinical Pharmacology·Flavia Franconi, Ilaria Campesi
Aug 21, 2014·Expert Opinion on Pharmacotherapy·Giuseppe DanieleRalph A DeFronzo
Oct 2, 2012·Diabetes Research and Clinical Practice·André J Scheen
Mar 1, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D Bolignano, C Zoccali
Apr 29, 2015·Bone·Christian MeierBeata Lecka-Czernik
Aug 7, 2012·Journal of the American Geriatrics Society·Troy H PuarJen M Ng
Jun 16, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·D J Betteridge
Mar 25, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·O J PhungC I Coleman
Mar 25, 2011·Diabetes/metabolism Research and Reviews·Salila Kurra, Ethel Siris
Apr 4, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Enzo Bonora, Massimo Cigolini
Jul 31, 2014·Diabetes, Obesity & Metabolism·W M Valencia, H Florez
Apr 26, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A PalermoN Napoli
Apr 24, 2016·Reviews in Endocrine & Metabolic Disorders·Avivit CahnItamar Raz
Dec 11, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F XiaoD Gu
May 28, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M BethelL D Carbone
Oct 26, 2016·Journal of Diabetes Research·Mohammed Al-Hariri
Feb 7, 2014·Reproductive Sciences·Vittorio UnferJean-Patrice Baillargeon
Jun 2, 2016·Journal of Cardiovascular Pharmacology and Therapeutics·Wenguang WangHongliang Cong
Aug 18, 2017·Critical Reviews in Toxicology·Melissa A DavidsonDaniel Krewski
Mar 5, 2015·Endocrine Reviews·Matthew P Gilbert, Richard E Pratley
Jun 4, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E LosadaD Prieto-Alhambra
Jun 30, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Khemayanto HidayatBi-Min Shi
Jun 21, 2017·Scientific Reports·Eladio Losada-GrandeDaniel Prieto-Alhambra
May 11, 2019·Environmental Health : a Global Access Science Source·Lariah EdwardsJennifer J Schlezinger
Oct 24, 2014·World Journal of Gastroenterology : WJG·Bülent Baran, Filiz Akyüz
Aug 11, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P JiaH Tang
May 31, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Faye V AndrewsJennifer J Schlezinger
Apr 3, 2021·Calcified Tissue International·Abdul Rahaman ShaikSerge Livio Ferrari
Jul 25, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Suhadinie GamageVijay Hegde

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.