Thiazolidinediones-improving endothelial function and potential long-term benefits on cardiovascular disease in subjects with type 2 diabetes

Journal of Diabetes and Its Complications
Paresh DandonaPriya Mohanty

Abstract

Endothelial dysfunction, which leads to impaired vasodilation, is an early event in the development of atherosclerosis. A number of mechanisms involving, for example, cell adhesion molecules, chemokines, and cytokines, contribute to this inflammatory disease, and insulin resistance plays a cardinal role in accelerating these processes. Hyperglycemia and other metabolic abnormalities that are commonly associated with insulin resistance also contribute to impaired endothelial function. In addition, the important role of the endothelium in damage repair following a cardiovascular event is emerging. The combination of proatherogenic factors in patients with type 2 diabetes results in blunted endothelial function and an increased risk of cardiovascular disease. Insulin-sensitizing agents such as thiazolidinediones have demonstrated a number of clinical benefits, including anti-inflammatory and antithrombotic properties, which may impact on the course of atherosclerosis. Recent studies have demonstrated that thiazolidinediones improve endothelial function in subjects with and without type 2 diabetes.

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Citations

Sep 21, 2010·Diabetes & Metabolism·C GarciaH Mayaudon
Jun 29, 2010·Atherosclerosis·Paresh DandonaHusam Ghanim
Apr 25, 2009·Ageing Research Reviews·Lan SunGuanhua Du
Sep 24, 2010·Preventive Cardiology·Philip R Liebson
Apr 2, 2015·Basic & Clinical Pharmacology & Toxicology·Linnéa Eriksson, Thomas Nyström
May 18, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Katerina K NakaLampros K Michalis

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