Thickened infant formula: What to know

Nutrition
Silvia SalvatoreY Vandenplas

Abstract

This study aimed to provide an overview of the characteristics of thickened formulas to aid health care providers manage infants with regurgitations. The indications, properties, and efficacy of different thickening agents and thickened formulas on regurgitation and gastroesophageal reflux in infants were reviewed. PubMed and the Cochrane database were searched up to December 2016. Based on the literature review, thickened formulas reduce regurgitation, may improve reflux-associated symptoms, and increase weight gain. However, clinical efficacy is related to the characteristics of the formula and of the infant. Commercial thickened formulas are preferred over the supplementation of standard formulas with thickener because of the better viscosity, digestibility, and nutritional balance. Rice and corn starch, carob bean gum, and soy bean polysaccharides are available as thickening agents. Hydrolyzed formulas have recently shown promising additional benefit. Thickened formulas reduce the frequency and severity of regurgitation and are indicated in formula-fed infants with persisting symptoms despite reassurance and appropriate feeding volume intake.

Citations

Feb 12, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Valeria DipasqualeClaudio Romano
Sep 19, 2019·Acta Paediatrica·Christophe Dupont, Yvan Vandenplas
Mar 23, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Jeaneth Indira Gonzalez AyerbeYvan Vandenplas
Dec 22, 2019·International Journal of Environmental Research and Public Health·Maria Elisabetta BaldassarreNicola Laforgia
May 18, 2019·Current Gastroenterology Reports·Daniel R DuncanRachel L Rosen
Feb 25, 2020·International Journal of Pediatrics·Changhun HanGa Won Jeon
Oct 20, 2020·Journal of Texture Studies·Olivia M RushMemorie M Gosa
Oct 30, 2020·Expert Opinion on Drug Safety·Melina SimonYvan Vandenplas
Nov 21, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Patrick TounianYvan Vandenplas
Jul 29, 2021·Pediatric Gastroenterology, Hepatology & Nutrition·Flavia IndrioMaroun Sokhn
Aug 22, 2021·Journal of Pediatric Gastroenterology and Nutrition·Marc BellaicheYvan Vandenplas

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