Thickening of multiple cranial nerves in a patient with extranodal peripheral T-cell lymphoma

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Sadaya MatanoTatsuho Sugimoto

Abstract

A 57-year-old male became aware of a subcutaneous tumor in March 2001. Histopathological examination showed peripheral T-cell lymphoma. He achieved complete remission after chemotherapy. Later the lymphoma relapsed in the subcutaneous lesion and chemotherapy was performed again. In April 2003, he developed diplopia, dysarthria, and dysphagia. Abnormal lymphoid cells were found in the cerebrospinal fluid. An immunophenotypical study disclosed that CD2, CD3, CD5, and CD8 were positive. Rearrangement of TCR was detected by Southern blotting. Cranial magnetic resonance imaging did not detect any intraparenchymal lesions, but thickening of multiple cranial nerves was detected. These nerves were homogeneously enhanced by gadolinium-DTPA. After intrathecal chemotherapy, atypical cells disappeared from the cerebrospinal fluid and thickening of the cranial nerves was resolved. Finally, lymphoma spread to the bone marrow, and the patient died in July 2003.

Citations

Apr 7, 2010·Blood·Sigal GrisariuUNKNOWN International Primary CNS Lymphoma Collaborative Group
Jun 3, 2014·Internal Medicine·Takeshi YoshidaManabu Jonosono
May 10, 2008·Neuroimaging Clinics of North America·Bruno A Policeni, Wendy R K Smoker
Dec 17, 2016·Clinical Case Reports·David BruceManil Subesinghe

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