Thicker carotid intima layer and thinner media layer in subjects with cardiovascular diseases. An investigation using noninvasive high-frequency ultrasound

Atherosclerosis
K A Rodriguez-MaciasT Naessen

Abstract

The thickness of the arterial intima increases and that of the media decreases with increasing age and degree of atherosclerosis. Separate estimates of the individual intima and media layers might therefore be more appropriate than the commonly used method estimating the combined intima-media thickness (IMT). One hundred consecutive 70-year-old subjects from the PIVUS study were investigated. Separate estimates of the thickness of the carotid artery intima and media wall layers were carried out noninvasively using 25MHz high-frequency ultrasound. Subjects with a diagnosis of cardiovascular disease (CVD), coronary heart disease (CHD), myocardial infarction (MI) or stroke had a significantly thicker intima layer (all P<0.0001) and a thinner media layer (all P<0.05) than healthy subjects. The intima/media thickness ratio also differed significantly between subjects with and without a diagnosis of CVD (0.43+/-0.20versus 0.75+/-0.48, P=0.0002). Subjects with hypertension or hyperlipidemia also had a thicker carotid intima than subjects without these diagnoses (P<0.0005 for both). None of the corresponding intima+media thickness values differed significantly. Similar results were obtained in women and men. Separate assessment of caro...Continue Reading

References

Dec 15, 1991·The American Journal of Cardiology·E J GussenhovenN Bom
Aug 23, 2001·Ultrasound in Medicine & Biology·K A Rodriguez-MaciasD Bergqvist
Dec 4, 2003·Atherosclerosis·Mark A EspelandSteven M Haffner
Jan 7, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Sei KomatsuKazuhisa Kodama

❮ Previous
Next ❯

Citations

Nov 21, 2007·Topics in Magnetic Resonance Imaging : TMRI·Tomas HansenLars Johansson
Jul 17, 2010·AJNR. American Journal of Neuroradiology·L SabaG Mallarini
Sep 20, 2012·Menopause : the Journal of the North American Menopause Society·Tord NaessenMark M Kushnir
Feb 23, 2013·Journal of Proteomics·Fernando de la CuestaMaria G Barderas
Jul 1, 2009·International Journal of Experimental Pathology·Siti Khadijah AdamKamsiah Jaarin
Nov 23, 2011·Journal of Clinical Ultrasound : JCU·Kar-Ho LauMichael Ying
Jan 1, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T AkhterT Naessen
Jun 4, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T AkhterT Naessen
Dec 30, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Walter OsikaPeter Friberg
Jun 2, 2012·Journal of Atherosclerosis and Thrombosis·Loan Thi Thanh TranHo-dirk Kim
Aug 1, 2019·Journal of the American Heart Association·Matthew ArnoldUNKNOWN China Kadoorie Biobank Collaborative Group
Nov 6, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Tansim AkhterTord Naessen
Aug 12, 2017·Clinical Science·Rachel J SkowMargie H Davenport
Jun 17, 2021·Journal of Human Hypertension·Luís F R S Carvalho-RomanoWilson Nadruz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.