Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy

Acta Ophthalmologica
Nihada CorajevicCecilia Rönnbäck

Abstract

To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6-83.5 years; best-corrected visual acuity (BCVA), 8-89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9-68.7; BCVA, 80-99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary RNFL. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis. The perifoveal RNFL, GCL, IPL and the peripapillary RNFL were all significantly th...Continue Reading

References

Feb 22, 2002·Molecular Genetics and Metabolism·Cécile DelettreChristian P Hamel
Oct 19, 2010·American Journal of Ophthalmology·Ana L LoducaMahnaz Shahidi
Jul 11, 2012·Orphanet Journal of Rare Diseases·Guy LenaersDan Milea
Jun 8, 2014·American Journal of Ophthalmology·Piero BarboniValerio Carelli
Nov 20, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sung Wook Park, Jeong-Min Hwang

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Citations

Sep 28, 2018·Acta Ophthalmologica·Bohdan KousalPetra Liskova
Feb 25, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Amélia MartinsJoão P Marques
Sep 15, 2020·Therapeutic Advances in Ophthalmology·Samuel AsanadOsamah J Saeedi
Nov 2, 2018·Investigative Ophthalmology & Visual Science·Chun-Yan WangJost B Jonas
Dec 20, 2020·Progress in Retinal and Eye Research·Guy LenaersBernd Wissinger
Sep 23, 2021·Scientific Reports·Isabelle MeunierGuy Lenaers

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