Thickness, phase retardation, birefringence, and reflectance of the retinal nerve fiber layer in normal and glaucomatous non-human primates.

Investigative Ophthalmology & Visual Science
Jordan C DwelleHenry G Rylander

Abstract

We identified candidate optical coherence tomography (OCT) markers for early glaucoma diagnosis. Time variation of retinal nerve fiber layer (RNFL) thickness, phase retardation, birefringence, and reflectance using polarization sensitive optical coherence tomography (PS-OCT) were measured in three non-human primates with induced glaucoma in one eye. We characterized time variation of RNFL thickness, phase retardation, birefringence, and reflectance with elevated intraocular pressure (IOP). One eye of each of three non-human primates was laser treated to increase IOP. Each primate was followed for a 30-week period. PS-OCT measurements were recorded at weekly intervals. Reflectance index (RI) is introduced to characterize RNFL reflectance. Associations between elevated IOP and RNFL thickness, phase retardation, birefringence, and reflectance were characterized in seven regions (entire retina, inner and outer rings, and nasal, temporal, superior and inferior quadrants) by linear and non-linear mixed-effects models. Elevated IOP was achieved in three non-human primate eyes with an average increase of 13 mm Hg over the study period. Elevated IOP was associated with decreased RNFL thickness in the nasal region (P = 0.0002), decreased...Continue Reading

Citations

Mar 28, 2013·Investigative Ophthalmology & Visual Science·Xiang-Run HuangXiao-Peng Zhao
Jun 7, 2015·Experimental Eye Research·Brad Fortune
Jun 14, 2015·Experimental Eye Research·Claude F Burgoyne
Mar 29, 2014·Journal of Applied Toxicology : JAT·Hyun-Kyu ParkWoo-Chan Son
Jan 17, 2015·Current Opinion in Ophthalmology·Tigran KostanyanJoel S Schuman
Jan 1, 2016·Expert Review of Ophthalmology·Katie A Lucy, Gadi Wollstein
Apr 5, 2019·Journal of Experimental Neuroscience·Michael R GardnerHenry G Rylander
Jul 1, 2017·Biomedical Optics Express·Johannes F de BoerYoshiaki Yasuno
Jan 29, 2016·Biomedical Optics Express·Xiang-Run HuangJianzhong Qiao
May 9, 2019·Biomedical Optics Express·Jia-Pu SyuWen-Chuan Kuo
May 12, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·William H SwansonStephen A Burns
May 27, 2021·Translational Vision Science & Technology·Riccardo CheloniJonathan Denniss

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