PMID: 9419250Feb 21, 1998Paper

ThiD-TenA: a gene pair fusion in eukaryotes

Journal of Molecular Evolution
C Ouzounis, N Kyrpides

Abstract

Computational analysis of the hypothetical open reading frame MJ0236 from Methanococcus jannaschii reveals its membership to a family of bacterial and eukaryotic proteins, predicted to be the HMP-P kinases involved in thiamin biosyntheis (ThiD). The eukaryotic members of this family contain a C-terminal extension similar to a bacterial transcriptional activator (TenA), thus pointing to a fusion event that took place during cellular evolution. The C-terminal domain is absent from M. jannaschii. The significance of this observation is two-fold: first, this is a case where a fusion protein contains two domains with an unusual phylogenetic distribution, and second, the TenA domain is a rare case of a gene family involved in transcription present both in bacteria and eukaryotes.

Citations

Mar 14, 2007·Archaea : an International Microbiological Journal·Richard M R CoulsonChristos A Ouzounis
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·N C Kyrpides, C A Ouzounis
Apr 11, 2013·Molecular BioSystems·Smita MohantyNambudiry Rekha

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