Thin cap fibroatheroma defined as lipid core abutting lumen (LCAL) on integrated backscatter intravascular ultrasound - comparison with optical coherence tomography and correlation with peri-procedural myocardial infarction

Circulation Journal : Official Journal of the Japanese Circulation Society
Yukio OzakiTakashi Muramatsu

Abstract

This study evaluated the ability of a newly developed integrated backscatter intravascular ultrasound (IB-IVUS) system (VISIWAVE, Terumo, Tokyo, Japan) to detect optical coherence tomography (OCT)-verified thin cap fibroatheroma (TCFA) and assessed the correlation with peri-procedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI). One hundred culprit lesions in 100 consecutive patients with ischemic heart disease who consented to repeated IVUS and OCT prior to PCI were studied. Of 100 lesions, 48 had OCT-verified TCFA with a cap thickness <65 µm. Such lesions had larger percentage lipid area and lipid angle >2 quadrants on IB-IVUS. A lipid core abutting lumen (LCAL) was defined as a lipid core pool in the plaque area, directly contacting with the lumen regardless of its circumferential extension. IB-IVUS-identified TCFA defined as a combination of percentage lipid area ≥53.6%, remodeling index ≥1.03, and the presence of LCAL was the best predictor of OCT-verified TCFA with sensitivity, specificity, positive and negative predictive values, and accuracy of 72.9%, 90.4%, 87.5%, 78.3%, and 82.0%, respectively. IB-IVUS-identified TCFA as well as OCT-verified TCFA were significant independent predictors o...Continue Reading

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Citations

Jan 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Shiro NakaharaIsao Taguchi
Jul 15, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Masanori Kawasaki
Mar 11, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Ari PollackJagat Narula
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Aug 1, 2018·JACC. Basic to Translational Science·Naoki WatanabeToyoaki Murohara
Jul 27, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Matthew SibbaldTej Sheth

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