Thin-layer MoS2 and thionin composite-based electrochemical sensing platform for rapid and sensitive detection of zearalenone in human biofluids

Biosensors & Bioelectronics
Keqiu JiangZheng Han

Abstract

In this study, a facile electrochemical sensing platform based on thin-layer MoS2 and thionin (MoS2-Thi) composites was constructed for the sensitive and rapid detection of zearalenone (ZEA) in human biofluids. MoS2-Thi composites with a thin-layer MoS2 structure and large specific surface area were synthesized via a simple ultrasound exfoliation method. To further enhance the performance of the platform but without increasing the complexity of the fabrication process, ZEA antibodies were modified with Pt nanoparticles (Pt NPs) using an environmentally friendly method, where they had a much wider linear range and four times higher sensitivity compared with the original ZEA monoclonal antibody (ZEA-MAb). Under the optimal conditions, the electrochemical responses of the MoS2-Thi composite-based immunosensor were linear (R2 = 0.9915) when the ZEA concentrations ranged from 0.01 to 50 ng mL-1. The proposed immunosensor could detect ZEA at concentrations as low as 0.005 ng mL-1 with excellent selectivity. The immunosensor exhibited acceptable stability with high reproducibility and accuracy, and it was applied successfully for determining ZEA in human plasma and urine samples. Our findings indicated that the proposed MoS2-Thi compo...Continue Reading

Citations

Mar 4, 2020·Toxins·Beatriz Arce-LópezElena González-Peñas
Nov 9, 2020·Biomaterials·Si MengS Meng
Jun 2, 2021·Critical Reviews in Food Science and Nutrition·Long WuGuozhen Liu
Jun 5, 2021·Biosensors & Bioelectronics·Emiliano Martínez-PeriñánEncarnación Lorenzo
Oct 12, 2021·Journal of Animal Science and Biotechnology·Runxian LiPingli He

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