Thin-section CT abnormalities and pulmonary gas exchange impairment in workers exposed to asbestos

Radiology
Andrea SetteNestor Müller

Abstract

To evaluate the relationship between abnormalities at thin-section computed tomography (CT) and indexes of pulmonary gas exchange impairment at rest and during moderate exercise in workers exposed to asbestos. Eighty-two workers with long-term exposure to asbestos and abnormal thin-section CT findings underwent respiratory physiologic measurements at rest (lung diffusing capacity, Dlco) and during exercise (oxygen uptake-corrected alveolar-arterial pressure difference for oxygen, DeltaP[A-a]O(2)/VO(2)). CT results were compared with physiologic measurements of impairment in gas exchange (Dlco < 70% predicted value and/or DeltaP[A-a]O(2)/VO(2) > 20 mm Hg. L. min(-1)). The CT findings were divided into five categories by using a previously described method. Odds ratios and 95% CIs for gas exchange defects were calculated for patients grouped according to CT findings. Logistic regression analysis was performed with gas exchange as the dependent response and CT abnormalities as independent variables. A significant association was found between extent of disease at CT and impairment of gas exchange (P <.01). Probability of functional impairment was increased with multifocal (class II) and diffuse (class III) CT abnormalities, partic...Continue Reading

References

Jan 1, 1979·Respiration; International Review of Thoracic Diseases·U ReinhardR M Schmülling
Apr 1, 1992·Seminars in Roentgenology·R BéginS Groleau
Jan 1, 1991·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·D G Altman, M J Gardner
Jan 1, 1991·International Journal of Clinical Monitoring and Computing·S HendersonR M Gardner
Apr 1, 1991·Seminars in Roentgenology·D R Aberle
Aug 1, 1990·Radiology·M AkiraT Kozuka
Jun 1, 1989·The American Review of Respiratory Disease·C A StaplesW R Webb
Jun 1, 1986·Journal of Applied Physiology·W L BeaverB J Whipp
May 1, 1988·The American Review of Respiratory Disease·J E CotesB King
Nov 1, 1988·AJR. American Journal of Roentgenology·D R AberleC S Ray
Jan 1, 1988·Advances in Experimental Medicine and Biology·P D Wagner
May 21, 1987·The New England Journal of Medicine·D Y SueK Wasserman
Mar 1, 1987·The American Journal of Cardiology·J E HansenK Wasserman
Sep 1, 1982·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·J HowardS K Koerner
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jan 1, 1995·AJR. American Journal of Roentgenology·G GamsuP D Blanc
Aug 1, 1993·British Journal of Industrial Medicine·R BéginP Bertrand
Nov 24, 1998·International Archives of Occupational and Environmental Health·P OksaP Laippala
May 29, 2000·BMJ : British Medical Journal·J M Bland, D G Altman
Jun 21, 2001·Scandinavian Journal of Work, Environment & Health·O HuuskonenT Vehmas
Jul 14, 2001·Chest·A E MedingerP K Rohatgi

❮ Previous
Next ❯

Citations

Feb 28, 2008·Current Opinion in Pulmonary Medicine·Torsten BlumTorsten Bauer
Feb 11, 2009·Journal of Thoracic Imaging·C Isabela S SilvaLuiz E Nery
Jul 28, 2011·Journal of Occupational Medicine and Toxicology·Dennis WilkenXaver Baur
May 31, 2011·Journal de radiologie·G Ferretti
Jan 24, 2008·American Journal of Industrial Medicine·José Henrique SettaLuiz Eduardo Nery
Feb 8, 2011·American Journal of Industrial Medicine·Cristiano Rabelo NogueiraLuiz E Nery
Dec 19, 2014·Inhalation Toxicology·Laura E KerperJulie E Goodman
Dec 21, 2011·Respiratory Medicine·Anne E HollandChristine F McDonald
Feb 23, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Matteo Bonini, Giuseppe Fiorenzano
Feb 3, 2007·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·José Alberto NederLuiz Eduardo Nery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.