Think globally, act locally: Centrosome-localized mRNAs ensure mitotic fidelity.

The Journal of Cell Biology
Daniela C Zarnescu

Abstract

The functional importance of mRNA localization to centrosomes is unclear. Ryder et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202004101) identify fragile-X mental retardation protein as a regulator of centrocortin (cen) mRNA dynamics in Drosophila. Mistargeting of cen impairs division and development, indicating that cen mRNA localization to centrosomes ensures mitotic fidelity.

References

Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark C AlliegroRobert E Palazzo
Jan 1, 2015·Nature Reviews. Molecular Cell Biology·Adina R BuxbaumRobert H Singer
Sep 17, 2015·Nature Reviews. Molecular Cell Biology·Paul T ConduitJordan W Raff
Apr 14, 2018·Traffic·Pearl V Ryder, Dorothy A Lerit
Nov 17, 2020·The Journal of Cell Biology·Pearl V RyderDorothy A Lerit

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