Nov 19, 2014

Thinking and acting beyond the positive: the role of the cognitive and negative symptoms in schizophrenia

CNS Spectrums
Maren Carbon, Christoph U Correll

Abstract

Since currently available antipsychotic medications predominantly treat hallucinations, delusions, disorganized thoughts and behavior, and related agitation/aggression, attention has traditionally been focused on managing positive symptoms. However, prominent negative symptoms and clinically relevant cognitive impairment affect approximately 40% and 80% of people with schizophrenia, respectively. Moreover, negative and cognitive symptoms are closely related to functional outcomes, and contribute substantially to the overall illness burden. Therefore, approaches to describe, measure, and manage these symptom domains are relevant. This article summarizes the phenomenology, prevalence, assessment, and treatment of negative and cognitive symptoms in patients with schizophrenia, including pharmacologic and nonpharmacologic management strategies that can be used in clinical care now, as well as pharmacologic approaches that are being tested. Currently, no approved treatments targeting negative or cognitive symptomatology in schizophrenia are available. It is hoped that progress in the understanding of the neurobiology of these important symptom domains of schizophrenia will help develop effective treatment strategies in the future. H...Continue Reading

Mentioned in this Paper

Antipsychotic Effect
Social Anhedonia
Neurobehavioral Manifestations
Schizophrenia
Antipsychotic Agents
Dysphasia
Neurobiology
Overinclusion
Schizophrenic Psychology
Agitation

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