Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region: a systematic review and meta-analysis

Infectious Diseases of Poverty
Jennifer A SteeleBruce A Wilcox

Abstract

Cholangiocarcinoma (CCA) is a fatal bile duct cancer associated with infection by the liver fluke, Opisthorchis viverrini, in the lower Mekong region. Numerous public health interventions have focused on reducing exposure to O. viverrini, but incidence of CCA in the region remains high. While this may indicate the inefficacy of public health interventions due to complex social and cultural factors, it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of CCA. This systematic review aims to provide a comprehensive analysis of described risk factors for CCA in addition to O. viverrini to guide future integrative interventions. We searched five international and seven Thai research databases to identify studies relevant to risk factors for CCA in the lower Mekong region. Selected studies were assessed for risk of bias and quality in terms of study design, population, CCA diagnostic methods, and statistical methods. The final 18 included studies reported numerous risk factors which were grouped into behaviors, socioeconomics, diet, genetics, gender, immune response, other infections, and treatment for O. viverrini. Seventeen risk factors were reported by two or more studies and w...Continue Reading

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Oct 5, 2019·Scientific Reports·Apiporn T SuwannatraiKinley Wangdi
Aug 31, 2018·Journal of Environmental and Public Health·William A SukMathuros Ruchirawat
Oct 31, 2020·Clinical and Experimental Pharmacology & Physiology·Abdifetah Ibrahim OmarKesara Na-Bangchang
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Feb 4, 2021·Current Problems in Surgery·T Peter KinghamMichael I D'Angelica
Aug 9, 2021·Acta Tropica·Oranard WattanawongBanchob Sripa

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