Thinking outside the box: recent advances in the analysis and presentation of uncertainty in cost-effectiveness studies

Annual Review of Public Health
Andrew BriggsGordon Blackhouse

Abstract

As many more clinical trials collect economic information within their study design, so health economics analysts are increasingly working with patient-level data on both costs and effects. In this paper, we review recent advances in the use of statistical methods for economic analysis of information collected alongside clinical trials. In particular, we focus on the handling and presentation of uncertainty, including the importance of estimation rather than hypothesis testing, the use of the net-benefit statistic, and the presentation of cost-effectiveness acceptability curves. We also discuss the appropriate sample size calculations for cost-effectiveness analysis at the design stage of a study. Finally, we outline some of the challenges for future research in this area-particularly in relation to the appropriate use of Bayesian methods and methods for analyzing costs that are typically skewed and often incomplete.

References

Jan 1, 1992·Annals of Internal Medicine·A D Oxman, G H Guyatt
Jul 1, 1990·Medical Decision Making : an International Journal of the Society for Medical Decision Making·W C Black
Aug 19, 1995·BMJ : British Medical Journal·D G Altman, J M Bland
Sep 1, 1994·Health Economics·B A van HoutF F Rutten
Nov 1, 1996·Health Economics·K Claxton, J Posnett
Apr 1, 1998·Medical Care·A P Hallstrom, S D Sullivan
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·P F Krabbe, G J Bonsel
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·D A AschM T Mennuti
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·K J CarterL M Gawdyda
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·J LipscombD B Matchar
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A A Stinnett, J Mullahy
May 5, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A H Briggs, A M Gray
Jul 31, 1998·Health Economics·M J AlF F Rutten
Oct 22, 1998·International Journal of Technology Assessment in Health Care·M TambourM Johannesson
Oct 24, 1998·BMJ : British Medical Journal·J M Bland, D G Altman
Jan 8, 1996·Journal of Health Economics·P FennD Jones
Apr 7, 1997·PharmacoEconomics·R L ObenchainD P Buesching
Sep 4, 1998·Journal of Health Services Research & Policy·A Briggs, A Gray
May 21, 1999·Lancet·I Pande, C Pritchard
May 29, 1999·Health Economics·B R Luce, K Claxton
May 29, 1999·Health Economics·D F HeitjanW Whang
May 29, 1999·Health Economics·A H Briggs
Oct 28, 1999·Journal of Health Economics·R D EtzioniS D Ramsey
Jun 22, 2000·Health Economics·D F Heitjan
Jun 30, 2000·International Journal of Technology Assessment in Health Care·J L Severens, G J van der Wilt
Mar 17, 2001·Health Economics·A H Briggs, B J O'Brien
Mar 29, 2001·Annual Review of Public Health·S D RamseyS D Sullivan
Jun 8, 2001·Statistics in Medicine·A R Willan, D Y Lin
Jul 27, 2001·Journal of Health Economics·W G Manning, J Mullahy
Mar 23, 2002·Annual Review of Public Health·Thomas LumleyLu Chen
Aug 23, 2003·Biostatistics·D Y Lin

❮ Previous
Next ❯

Citations

Nov 6, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Peter FritzellHans Tropp
Jan 27, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Carlo LazzaroAntonio Uccelli
Dec 8, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Sonja MerkesdalAndrea Rubbert-Roth
Mar 18, 2008·Administration and Policy in Mental Health·David S SalkeverElizabeth A Stuart
Nov 2, 2005·Breast Cancer Research and Treatment·Louisa G GordonBeth Newman
Jul 6, 2006·Breast Cancer Research and Treatment·Khalid El OuagariJane Brandman
Sep 25, 2009·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M J HarrisonUNKNOWN British Society for Rheumatology Biologics Register Control Centre Consortium
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bernie J O'BrienStuart J Connolly
Sep 6, 2003·Drug and Alcohol Dependence·Christopher M DoranJames Bell
Aug 13, 2003·Kidney International·Philip A McFarlaneDonald A Redelmeier
May 22, 2003·The New England Journal of Medicine·Scott D RamseyUNKNOWN National Emphysema Treatment Trial Research Group
May 23, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe BorianiCarlo Lazzaro
Apr 21, 2011·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Dario GregoriEva Pagano
Feb 6, 2003·Journal of the National Cancer Institute·Wilbert B van den HoutJan Willem H Leer
Mar 30, 2004·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Kevin D FrickLinda P Fried
Jul 14, 2010·The Journal of Trauma·Ellen J MacKenzieDavid S Salkever
Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B StoykovaH C Kitchener
Apr 20, 2004·The British Journal of Ophthalmology·H-H König, J-C Barry
Jan 16, 2007·Annual Review of Public Health·Scott D GrosseAnne C Haddix
Jan 13, 2009·American Journal of Respiratory and Critical Care Medicine·Nick A AnticR Doug McEvoy
Mar 3, 2011·Psychiatric Services : a Journal of the American Psychiatric Association·Jason N DoctorNorah C Feeny
Sep 13, 2012·The International Journal of Behavioral Nutrition and Physical Activity·Marieke F van WierMaurits W van Tulder
Mar 17, 2009·Critical Care : the Official Journal of the Critical Care Forum·Kate A HaltonNicholas Graves
Sep 3, 2011·Journal of Oncology Practice·Michael GrabnerC Daniel Mullins
Jan 30, 2014·PloS One·Falk SchwendickeSebastian Paris
Jun 21, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Dean A RegierCarlo A Marra
May 6, 2008·Proceedings of the American Thoracic Society·Scott D RamseyRobert M Kaplan
Oct 31, 2013·International Journal of Environmental Research and Public Health·Héctor José NavarroDennis J Petrie
Jun 4, 2010·The American Journal of Tropical Medicine and Hygiene·Yodi MahendradhataPatrick Van der Stuyft
May 24, 2014·Journal of Occupational and Environmental Medicine·Johanna M van DongenJudith E Bosmans
Jan 11, 2014·Applied Health Economics and Health Policy·Haitham W TuffahaPaul A Scuffham

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.