Thinking outside the cell: how cadherins drive adhesion.

Trends in Cell Biology
Julia BraschLawrence Shapiro

Abstract

Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain multiple repeats of β-sandwich extracellular cadherin (EC) domains that adopt a similar fold to immunoglobulin domains. The best characterized cadherins are the vertebrate 'classical' cadherins, which mediate adhesion via trans homodimerization between their membrane-distal EC1 domains that extend from apposed cells, and assemble intercellular adherens junctions through cis clustering. To form mature trans adhesive dimers, cadherin domains from apposed cells dimerize in a 'strand-swapped' conformation. This occurs in a two-step binding process involving a fast-binding intermediate called the 'X-dimer'. Trans dimers are less flexible than cadherin monomers, a factor that drives junction assembly following cell-cell contact by reducing the entropic cost associated with the formation of lateral cis oligomers. Cadherins outside the classical subfamily appear to have evolved distinct adhesive mechanisms that are only now beginning to be understood.

References

Mar 23, 1995·Nature·L ShapiroW A Hendrickson
Feb 1, 1994·Developmental Biology·U Tepass, V Hartenstein
Dec 1, 1995·Protein Science : a Publication of the Protein Society·M J BennettD Eisenberg
Jun 24, 1997·Biochemistry·A W KochJ Engel
Feb 9, 2000·The Journal of Cell Biology·W S ShanL Shapiro
Apr 20, 2002·Science·Titus J BoggonLawrence Shapiro
May 15, 2002·Genes, Chromosomes & Cancer·Karen M Hajra, Eric R Fearon
May 29, 2003·Biophysical Journal·B ZhuD Leckband
Oct 31, 2003·Molecular and Cellular Biology·Regina B TroyanovskySergey M Troyanovsky
Dec 17, 2003·Current Opinion in Structural Biology·Saurabh D PatelLawrence Shapiro
Apr 9, 2004·The EMBO Journal·Daniel HäussingerStephan Grzesiek
Nov 25, 2004·Seminars in Cell & Developmental Biology·Albert B Reynolds, Robert H Carnahan
Jul 19, 2005·Nature Reviews. Molecular Cell Biology·Barry M Gumbiner
Aug 25, 2005·Journal of Cell Science·Oliver J HarrisonPeter J Kilshaw
Dec 6, 2005·Biophysical Journal·Marco V BayasDeborah Leckband
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zubair M AhmedThomas B Friedman
Apr 13, 2007·Annual Review of Neuroscience·Melissa A VollrathDavid P Corey
Dec 20, 2007·The Journal of Biological Chemistry·Tomas D PerezW James Nelson
Feb 16, 2008·Science·Monika Abedin, Nicole King
Mar 11, 2008·Biophysical Journal·Marcos Sotomayor, Klaus Schulten
Apr 24, 2008·Development, Growth & Differentiation·Takeshi Yagi
Oct 14, 2008·The International Journal of Biochemistry & Cell Biology·Paco Hulpiau, Frans van Roy
Jun 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·P KatsambaBarry H Honig
Aug 4, 2009·Structure·Sanjeevi SivasankarSteven Chu
Aug 15, 2009·Current Opinion in Cell Biology·Richelle Sopko, Helen McNeill
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Takashi WatanabeKozo Kaibuchi
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Lawrence Shapiro, William I Weis
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Soonjin HongSergey M Troyanovsky
Mar 2, 2010·Nature Structural & Molecular Biology·Oliver J HarrisonLawrence Shapiro
Mar 2, 2010·Nature Structural & Molecular Biology·Carlo CiattoLawrence Shapiro
Apr 20, 2010·Neuron·Marcos SotomayorDavid P Corey
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Wenxiang Meng, Masatoshi Takeichi

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Citations

Feb 12, 2014·The Journal of Chemical Physics·Zhong-Ru XieYinghao Wu
May 6, 2014·Trends in Cell Biology·Marcos SotomayorDavid P Corey
Dec 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jacques U Baenziger
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mark LommelSabine Strahl
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Malene B Vester-ChristensenHenrik Clausen
Nov 12, 2014·Nature Communications·Charlotte H ColesA Radu Aricescu
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sabyasachi RakshitSanjeevi Sivasankar
Mar 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ruishuang GengKumar N Alagramam
Jun 8, 2013·Science·Charlène Guillot, Thomas Lecuit
Apr 3, 2013·The Journal of Cell Biology·Soonjin HongSergey M Troyanovsky
Jan 22, 2014·The Journal of Cell Biology·Christopher P ToretW James Nelson
Aug 12, 2015·The Journal of Cell Biology·Chi-Shuo ChenSergey M Troyanovsky
Mar 17, 2015·Stem Cell Research·Stella Alimperti, Stelios T Andreadis
Dec 17, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Franziska VielmuthVolker Spindler
Oct 13, 2015·Current Biology : CB·Tao JiangTony J C Harris
Jul 3, 2013·The Journal of Investigative Dermatology·Sanjeevi Sivasankar
Sep 24, 2013·The Journal of Investigative Dermatology·Dana K TuckerAndrew P Kowalczyk
May 4, 2013·The Journal of Investigative Dermatology·Indrajyoti IndraSergey Troyanovsky
Nov 2, 2015·Trends in Cell Biology·Brenton D Hoffman, Alpha S Yap
Oct 16, 2015·Developmental Cell·Alpha S YapRobert G Parton
May 9, 2013·Molecular Microbiology·Mohd Farid Abdul HalimMechthild Pohlschroder
Feb 14, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Zhe SunGerald A Meininger
Jan 23, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Stina LindénNiko Hildebrandt
Dec 9, 2014·Cell Adhesion & Migration·Annette GärtnerCarlos G Dotti
Sep 30, 2015·The Journal of Cell Biology·Sylvain BessonnardDaniel B Constam
Apr 29, 2015·Cell Adhesion & Migration·Eunju SeongJyothi Arikkath
Oct 2, 2014·Protein Science : a Publication of the Protein Society·Zhong-Ru XieYinghao Wu
Apr 19, 2015·Current Opinion in Structural Biology·Kwok-Ho Lam, Rongsheng Jin
Nov 18, 2015·Journal of Chemical Theory and Computation·Fabio DoroFrancesco L Gervasio

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