Thinner Regions of Intracranial Aneurysm Wall Correlate with Regions of Higher Wall Shear Stress: A 7T MRI Study.

AJNR. American Journal of Neuroradiology
R BlankenaJ J M Zwanenburg

Abstract

Both hemodynamics and aneurysm wall thickness are important parameters in aneurysm pathophysiology. Our aim was to develop a method for semi-quantitative wall thickness assessment on in vivo 7T MR images of intracranial aneurysms for studying the relation between apparent aneurysm wall thickness and wall shear stress. Wall thickness was analyzed in 11 unruptured aneurysms in 9 patients who underwent 7T MR imaging with a TSE-based vessel wall sequence (0.8-mm isotropic resolution). A custom analysis program determined the in vivo aneurysm wall intensities, which were normalized to the signal of nearby brain tissue and were used as measures of apparent wall thickness. Spatial wall thickness variation was determined as the interquartile range in apparent wall thickness (the middle 50% of the apparent wall thickness range). Wall shear stress was determined by using phase-contrast MR imaging (0.5-mm isotropic resolution). We performed visual and statistical comparisons (Pearson correlation) to study the relation between wall thickness and wall shear stress. 3D colored apparent wall thickness maps of the aneurysms showed spatial apparent wall thickness variation, which ranged from 0.07 to 0.53, with a mean variation of 0.22 (a variat...Continue Reading

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Citations

Jul 25, 2019·Journal of Neurointerventional Surgery·Edgar A SamaniegoDavid Hasan
Jun 20, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Khalid M SaqrMakoto Ohta
May 12, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jae W SongZhaoyang Fan
Jun 27, 2020·AJNR. American Journal of Neuroradiology·L M GottwaldA J Nederveen
Nov 16, 2019·AJNR. American Journal of Neuroradiology·J W SongL A Loevner
Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·Oriane PoupartDominique P Pioletti
Apr 30, 2021·Neurosurgical Review·Hamidreza Rajabzadeh-OghazVincent M Tutino

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