ThinPrep vitreous-based diagnosis of choroidal malignant melanoma

Ocular Immunology and Inflammation
Annie ChanDarius M Moshfeghi

Abstract

To report an alternative method for the diagnosis of atypical choroidal malignant melanoma-ThinPrep sampling of the vitreous cavity through 25-gauge vitrectomy. Case report. A 79-year-old gentleman presented with a progressive decline in visual acuity in his left eye. A clinical diagnosis of large choroidal malignant melanoma was made. Given the history of trauma and the possibility of enucleation, the patient wished to have histopathological confirmation. The patient underwent 25-gauge vitrectomy. However, he developed a choroidal hemorrhage during the procedure and the surgeon elected not to perform transretinal biopsy. Instead a sample of the vitreous was evaluated by ThinPrep analysis, and a diagnosis of choroidal malignant melanoma was made. Cytological evaluation of vitreous substance with ThinPrep may provide an alterative method for a diagnosis in select cases in which FNA is not possible or desirable. This technique is straightforward and minimizes the risk of retinal detachment or hemorrhage.

References

Jan 1, 1988·Survey of Ophthalmology·K M EganD M Albert
May 7, 2002·Diagnostic Cytopathology·Güliz Akdas BarkanClaire W Michael

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Citations

Jun 5, 2012·Journal français d'ophtalmologie·T SakumaR Takamizu
May 21, 2011·Acta Ophthalmologica·Neil Abi-AyadLaurent Kodjikian

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