PMID: 8942337Oct 1, 1996Paper

Thiobarbiturates suppress depolarization-induced contraction of vascular smooth muscle without suppression of calcium influx

British Journal of Anaesthesia
R KitamuraK Mori

Abstract

We have studied the effects of barbiturates on vascular smooth muscle tension and cytosolic calcium concentrations ([Ca2+]i) in endothelium-denuded rat aortic rings, preloaded with fluo-3. Changes in [Ca2+]i were estimated by the fluorescence intensity of the calcium-bound form of fluo-3. In aortic rings under basal conditions, thiobarbiturates (thiopentone and thiamylal 100-300 mumol litre-1) increased [Ca2+]i, concomitantly with an increase in tension, although oxybarbiturates (pentobarbitone and secobarbitone up to 300 mumol litre-1) had no effect. Thiopentone (300 mumol litre-1)-induced increases in tension and fluorescence intensity were mean 25.1 (SD 3.2)% and 55.0 (6.0)%, respectively, of those induced by KCl 30 mmol litre-1 (n = 8, each). In KCl (30 mmol litre-1)-precontracted aortic rings, thiopentone decreased tension without reduction of [Ca2+]i, whereas pentobarbitone decreased tension and [Ca2+]i, KCl (30 mmol litre-1)-induced contraction was suppressed by pretreatment with all barbiturates (100-300 mumol litre-1); thiopentone 300 mumol litre-1 suppressed contraction to 64.8 (2.5)% (n = 6) and pentobarbitone 300 mumol litre-1 to 57.5 (2.2)% (n = 9). However, the increase in [Ca2+]i was suppressed by oxybarbiturates...Continue Reading

Citations

Dec 23, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M KakuyamaK Mori
Aug 18, 2000·Anaesthesia·I M Aguilera, R S Vaughan
Feb 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Sinan GursoyCaner Mimaroglu
Oct 23, 2003·Anesthesia and Analgesia·Masami SatoKazuhiko Fukuda
Nov 8, 2001·Canadian Journal of Physiology and Pharmacology·R KitamuraK Fukuda
Oct 23, 2002·Critical Reviews in Toxicology·Janne HukkanenHannu Raunio

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