PMID: 14698229Dec 31, 2003

Thioester-containing proteins and insect immunity

Molecular Immunology
Stéphanie Blandin, Elena A Levashina

Abstract

Here, we discuss the role of thioester-containing proteins in innate immune responses of insects. TEPs are represented by multi-member families both in the fruitfly, Drosophila melanogaster, and in the mosquito, Anopheles gambiae. Phylogenetic analysis of the family suggests that in these two dipteran species evolution of TEPs followed independent scenarios as a result of specific adaptation to distinct ecological environments. Research on these two relatively simple model systems, which lack adaptive immunity, may provide new insights into the evolutionary origins and functions of this important protein family.

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Related Concepts

Immune Response
Immune System
Protein Family
Thioester
Phylogeny
Anopheles gambiae
Adaptive Immunity
Diptera
Insect Extract
Drosophila melanogaster

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