Thioesterase II of Escherichia coli plays an important role in 3-hydroxydecanoic acid production

Applied and Environmental Microbiology
Zhong ZhengGuo-Qiang Chen

Abstract

3-Hydroxydecanoic acid (3HD) was produced in Escherichia coli by mobilizing (R)-3-hydroxydecanoyl-acyl carrier protein-coenzyme A transacylase (PhaG, encoded by the phaG gene). By employing an isogenic tesB (encoding thioesterase II)-negative knockout E. coli strain, CH01, it was found that the expressions of tesB and phaG can up-regulate each other. In addition, 3HD was synthesized from glucose or fructose by recombinant E. coli harboring phaG and tesB. This study supports the hypothesis that the physiological role of thioesterase II in E. coli is to prevent the abnormal accumulation of intracellular acyl-coenzyme A.

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Citations

Feb 9, 2005·Applied Microbiology and Biotechnology·Guo-Qiang Chen, Qiong Wu
Jul 5, 2007·Applied Microbiology and Biotechnology·Qian LiuGuo-Qiang Chen
May 8, 2008·Applied Microbiology and Biotechnology·Sang-Hyun LeeSoon Ho Hong
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hsien-Chung Tseng, Kristala L J Prather
Mar 24, 2009·Applied and Environmental Microbiology·Hsien-Chung TsengKristala L Jones Prather
Sep 20, 2011·Applied and Environmental Microbiology·Parwez NawabiAthanasios Lykidis
Jan 11, 2014·Biotechnology for Biofuels·Helge Jans Janßen, Alexander Steinbüchel
Jan 15, 2014·Applied Microbiology and Biotechnology·Frank SonntagJens Schrader
May 18, 2006·The FEBS Journal·Puja ShahiRavinder S Jolly
Jun 10, 2011·Journal of Basic Microbiology·Yangmin GongMulang Jiang
Jun 28, 2011·Current Opinion in Biotechnology·Xue GaoGuo-Qiang Chen
May 21, 2014·PloS One·Mateusz G AdamskiAlison E Baird
Feb 7, 2012·Journal of the American Academy of Dermatology·Johann E GudjonssonCharles N Ellis
Jan 10, 2018·Biotechnology and Bioengineering·Seohyoung Kim, Ramon Gonzalez
Mar 6, 2019·Applied Microbiology and Biotechnology·Mónica Guevara-MartínezAntonius J A van Maris
May 3, 2019·Applied Microbiology and Biotechnology·Dragan MiscevicC Perry Chou
Feb 7, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Crystall M D SwarbrickJade K Forwood
Mar 25, 2017·Canadian Journal of Microbiology·Rahul UkeyAndrei Y Chistoserdov
Sep 1, 2008·EcoSal Plus·John E Cronan, Charles O Rock

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