Thioether crosslinkages created by a radical SAM enzyme

Chembiochem : a European Journal of Chemical Biology
Qi Zhang, Yi Yu

Abstract

Unusually versatile: While the β-carbon thioether linkage in lantibiotics has long been appreciated and is relatively well characterized, a recent publication shows that the unusual sulfur-to-α-carbon thioether crosslinks in subtilosin A are produced by a radical SAM enzyme, AlbA, that contains two [4 Fe-4 S] clusters, thus highlighting the versatility of post-translational modifications in natural product biosynthesis.

References

Jul 18, 1997·Biochemical and Biophysical Research Communications·D Guianvarc'hA Marquet
Jan 6, 2004·Science·Frederick BerkovitchCatherine L Drennan
Jan 31, 2004·Science·Lili XieWilfred A van der Donk
Aug 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Petra Hänzelmann, Hermann Schindelin
Sep 2, 2004·The Journal of Biological Chemistry·Fabien PierrelMohamed Atta
Feb 2, 2006·Journal of the American Chemical Society·Leah M MillerNeil L Kelleher
Apr 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Petra Hänzelmann, Hermann Schindelin
Oct 3, 2006·Bioorganic & Medicinal Chemistry·Masaru HashimotoHyouta Himeno
May 18, 2007·Annual Review of Microbiology·Joanne M Willey, Wilfred A van der Donk
Nov 16, 2007·Journal of the American Chemical Society·Kenichi YokoyamaTadashi Eguchi
Nov 24, 2007·FEMS Microbiology Reviews·Mercedes MaquedaManuel Martínez-Bueno
Mar 1, 2008·Critical Reviews in Biochemistry and Molecular Biology·Perry A FreyFrank J Ruzicka
Aug 1, 2009·Natural Product Reports·John A McIntoshEric W Schmidt
Dec 18, 2009·Nature Chemical Biology·Trent J Oman, Wilfred A van der Donk
Jan 30, 2010·Natural Product Reports·Chaoxuan Li, Wendy L Kelly
Mar 3, 2010·Applied Microbiology and Biotechnology·Kaarina SivonenJouni Jokela
May 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mary C ReaColin Hill
Jun 5, 2010·The Journal of Biological Chemistry·Christopher T WalshAlbert A Bowers
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wei-Ting LiuPieter C Dorrestein
Nov 26, 2010·Current Opinion in Chemical Biology·Juan E Velásquez, Wilfred A van der Donk
Jan 5, 2011·Nature Chemical Biology·Trent J OmanWilfred A van der Donk
Apr 30, 2011·Journal of the American Chemical Society·Clarissa S SitJohn C Vederas
Jul 21, 2011·The Journal of Biological Chemistry·Qi Zhang, Wen Liu
Mar 1, 2012·Nature Chemical Biology·Leif FlüheMohamed A Marahiel

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Citations

Nov 13, 2012·Current Opinion in Structural Biology·Krista A Shisler, Joan B Broderick
Mar 31, 2016·Chembiochem : a European Journal of Chemical Biology·Wei DingQi Zhang
Feb 28, 2018·Natural Product Reports·Mark W RuszczyckyHung-Wen Liu
Oct 1, 2019·Angewandte Chemie·Tianlu MoQi Zhang
Apr 7, 2015·ACS Chemical Biology·Wei DingQi Zhang
Sep 8, 2021·Journal of the American Chemical Society·Ronald A BesandreHung-Wen Liu

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