Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels

Journal of Controlled Release : Official Journal of the Controlled Release Society
Joseph C GrimKristi S Anseth

Abstract

Hydrogels have emerged as promising scaffolds in regenerative medicine for the delivery of biomolecules to promote healing. However, increasing evidence suggests that the context that biomolecules are presented to cells (e.g., as soluble verses tethered signals) can influence their bioactivity. A common approach to deliver biomolecules in hydrogels involves physically entrapping them within the network, such that they diffuse out over time to the surrounding tissues. While simple and versatile, the release profiles in such system are highly dependent on the molecular weight of the entrapped molecule relative to the network structure, and it can be difficult to control the release of two different signals at independent rates. In some cases, supraphysiologically high loadings are used to achieve therapeutic local concentrations, but uncontrolled release can then cause deleterious off-target side effects. In vivo, many growth factors and cytokines are stored in the extracellular matrix (ECM) and released on demand as needed during development, growth, and wound healing. Thus, emerging strategies in biomaterial chemistry have focused on ways to tether or sequester biological signals and engineer these bioactive scaffolds to signal...Continue Reading

References

Dec 1, 1991·Journal of Biomedical Materials Research·W R GombotzA S Hoffman
Feb 8, 1980·Molecular and Cellular Biochemistry·E PearlsteinA Garcia-Pardo
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
Sep 1, 1996·Biomaterials·K S AnsethL Brannon-Peppas
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N A PeppasH Ichikawa
Jul 15, 2000·Journal of Biomaterials Science. Polymer Edition·S J BryantK S Anseth
Jan 12, 2002·Current Opinion in Structural Biology·L Pellegrini
Mar 28, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Anna Paola Pelliccioli, Jakob Wirz
Apr 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·M P LutolfJ A Hubbell
Apr 22, 2003·Nature Biotechnology·Matthias P LutolfJeffrey A Hubbell
Jul 5, 2003·International Journal of Pharmaceutics·Andreas Bernkop-SchnürchTheresa Zoidl
Aug 19, 2003·Biomaterials·Jeanie L Drury, David J Mooney
Aug 19, 2003·Biomaterials·Heungsoo ShinAntonios G Mikos
Aug 19, 2003·Biomaterials·Ulrich HerselHorst Kessler
Oct 18, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andreas H ZischJeffrey A Hubbell
Oct 29, 2003·Current Opinion in Biotechnology·Tanyarut Boontheekul, David J Mooney
Nov 19, 2003·Mechanisms of Development·Danielle J Behonick, Zena Werb
Mar 23, 2004·Nature Materials·Ying Luo, Molly S Shoichet
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Jeffrey H Miner, Peter D Yurchenco
Nov 19, 2004·Journal of the American Chemical Society·Nicholas J AgardCarolyn R Bertozzi
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Nov 4, 2006·Advanced Drug Delivery Reviews·Chien-Chi Lin, Andrew T Metters
Sep 26, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lingyun LiuShaoyi Jiang
Feb 23, 2008·Journal of Tissue Engineering and Regenerative Medicine·P C BessaR L Reis
Feb 26, 2008·Cell·Juergen A Knoblich
Mar 19, 2008·Angewandte Chemie·Svea PetersenAranzazu del Campo
May 7, 2008·Biomedical Materials·Patricia Musoke-Zawedde, Molly S Shoichet
Jul 29, 2008·Biophysical Journal·Krishanu SahaKevin E Healy
Aug 9, 2008·Advanced Functional Materials·Danielle S W BenoitKristi S Anseth
Sep 19, 2008·Journal of the American Chemical Society·Melissa L BlackmanJoseph M Fox
Oct 14, 2008·Annals of Biomedical Engineering·Tracy Jane Stefonek-Puccinelli, Kristyn S Masters
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gregory S Schultz, Annette Wysocki
Aug 29, 2009·Angewandte Chemie·Ellen M Sletten, Carolyn R Bertozzi

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Citations

Mar 2, 2016·Current Opinion in Biotechnology·Ana M PorrasKristyn S Masters
Jan 12, 2017·Advanced Materials·Eva BlascoChristopher Barner-Kowollik
Nov 22, 2017·Chemistry : a European Journal·Teresa L RappIvan J Dmochowski
Aug 16, 2017·Natural Product Reports·Alexander Kornienko, James J La Clair
Dec 5, 2017·Chemical Communications : Chem Comm·Shanshan LyuHongbin Li
Nov 24, 2018·Macromolecular Rapid Communications·Hatice MutluPatrick Theato
Nov 12, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Samantha J WojdaSeth W Donahue
Nov 20, 2016·Macromolecular Rapid Communications·Gioia Della GiustinaGiovanna Brusatin
Jan 17, 2017·Materials Horizons·Junmin LeeKristopher A Kilian
Jan 4, 2019·Tissue Engineering and Regenerative Medicine·Kyung Min Park, Ki Dong Park
Feb 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao HeChangsheng Zhao
Apr 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cassandra L PetrouChelsea M Magin
Jan 25, 2021·Advanced Drug Delivery Reviews·Teresa L Rapp, Cole A DeForest
May 28, 2019·Progress in Biophysics and Molecular Biology·Claudia CrociniLeslie A Leinwand
Feb 2, 2021·Biomaterials Science·M Gregory Grewal, Christopher B Highley
Mar 5, 2021·Chemical Reviews·Bauke AlbadaFloris van Delft
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Vega Widya KarismaJulia Li Zhong
Feb 23, 2021·Frontiers in Chemistry·Yanyu Zhang, Yishun Huang
Jul 20, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Anthony J BergerPamela K Kreeger
Feb 10, 2018·Trends in Biotechnology·Nick HuettnerAurelien Forget
Apr 7, 2021·Chemical Reviews·Kiall F SuazoMark D Distefano
Apr 10, 2021·Chemical Reviews·Benjamin D FairbanksChristopher N Bowman
Apr 27, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cong WangJian Ji
Jun 23, 2021·Essays in Biochemistry·Alessia LongoniKhoon S Lim
Apr 6, 2018·ACS Applied Materials & Interfaces·Lingli LiTimothy C Hughes
Jan 15, 2019·ACS Macro Letters·Paige J LeValley, April M Kloxin
May 24, 2019·Molecular Pharmaceutics·Karthik NadendlaSimon H Friedman
Sep 18, 2021·Biomacromolecules·Marzieh MonfaredMartina H Stenzel

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