Thiol proteases: inhibitors and potential therapeutic targets

Current Medicinal Chemistry
Regis Leung-ToungMichael Spino

Abstract

A better understanding of the biological roles and the pathological consequences of thiol-dependent enzymes has emerged in recent years, and hence considerable progress has been made in identifying and delineating cysteine proteases that can be considered promising drug targets from those involved in housekeeping functions. Cysteine proteases have been implicated in a wide variety of disease processes ranging from cardiovascular, inflammatory, viral and immunological disorders to cancer. The first milestone in drug development of cysteine protease inhibitors has probably been reached, as IDN-6556 (a broad spectrum caspase inhibitor) has recently received Orphan Drug label by the U.S. Food and Drug Administration for use in the treatment of the patients undergoing liver transplantation and other solid organ transplantation. IDN-6556, which blocks apoptosis, is in Phase II human clinical trial in patients undergoing liver transplantation. In addition, more than ten cysteine protease inhibitors are presently at various phases of clinical development/trials for diverse diseases. This review emphasises on the new development from the literature reports since the year 2000 in the exploration of potential cysteine proteases as prospec...Continue Reading

Citations

Apr 21, 2009·Chemical Reviews·Thomas W MillerDavid D Roberts
Dec 25, 2008·Journal of the American Chemical Society·Aman IqbalChristopher J Schofield
Jun 15, 2007·Nature Cell Biology·Nikita PopovMartin Eilers
Mar 31, 2007·Nature Reviews. Drug Discovery·David C RubinszteinDaniel J Klionsky
Dec 6, 2007·BMC Biochemistry·Philippe Guédat, Frédéric Colland
Sep 22, 2010·PLoS Neglected Tropical Diseases·Yen Ting ChenWilliam R Roush
Feb 21, 2013·Journal of Lipid Research·Luz CamachoTimothy M Thomson
Apr 25, 2009·Expert Opinion on Investigational Drugs·Dieter Brömme, Fabien Lecaille
Oct 27, 2007·Biochimie·Laurent Daviet, Frédéric Colland
Oct 16, 2007·Biochimie·Fabien LecailleGilles Lalmanach
Jun 25, 2015·Carcinogenesis·Kannan Badri NarayananHyun Ho Park
Jun 12, 2013·Autophagy·Marie A Kong-HapSébastien Besteiro
Jan 31, 2017·Scientia pharmaceutica·Mary Snow SetzerWilliam N Setzer
Aug 20, 2014·Organic & Biomolecular Chemistry·William DohertyAndrew Knox
Jan 10, 2013·Organic & Biomolecular Chemistry·Xing-Feng RenShuxue Zou
Oct 13, 2006·Journal of Medicinal Chemistry·Andrew W PattersonJonathan A Ellman
Jan 8, 2015·Journal of Medicinal Chemistry·Arun K Ghosh, Margherita Brindisi
May 26, 2009·Bioorganic & Medicinal Chemistry Letters·Isak ImYong-Chul Kim
Dec 29, 2020··Лариса Ивановна ЩербаковаАлексей Сергеевич Чиряпкин

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2021 Meta ULC. All rights reserved