PMID: 19928123Nov 26, 2009Paper

Thiolated chitosan nanoparticles as an oral delivery system for Amikacin: in vitro and ex vivo evaluations

Journal of Nanoscience and Nanotechnology
Fatemeh AtyabiRassoul Dinarvand

Abstract

The purpose of this study was the synthesis of two thiol conjugated Chitosan polymers, and evaluation of the potential of Thiomer nanoparticle formulation as a carrier for oral delivery system. Mediated by EDAC (Ethylene-3-(3-di-methylaminopropyl)-carbodiimide), either N-acetyl Cysteine (NAC) or N-acetyl D-penicillamine (NAP) were covalently attached to Chitosan. The success of the synthesis was demonstrated by comparing FTIR spectra. Iodometric titration demonstrated that depending on the pH value of the synthesis medium, the Thiomers display 250 +/- 30 microMol and 300 +/- 20 microMol thiol groups per gram of polymer respectively. The interaction between mucin and Thiomers, compared to mucin and Chitosan was studied for assessment of mucoadhesion properties of synthesized polymers. This interaction was determined by the measurement of the amount of mucin adsorbed on Chitosan and the conjugated polymers. Rotating cylinder method demonstrated an average of 20 times improvement in mucoadhesion of Thiomers compared to the unmodified polymer. Chitosan and Thiomer nanoparticles were formulated by two methods; TPP and Sodium Sulfate gelation. SEM micrographs and data achieved by a Malvern nano/zetasizer show nanoparticles formed by ...Continue Reading

Citations

Feb 12, 2013·Nanoscale Research Letters·Liqin JiangQiqing Zhang
Feb 4, 2011·International Journal of Nanomedicine·Solmaz GhaffariFatemeh Atyabi
Oct 7, 2011·International Journal of Nanomedicine·Parisa YousefpourRassoul Dinarvand
May 19, 2012·International Journal of Nanomedicine·Hosniyeh HosseinzadehSeyed Naser Ostad
Apr 30, 2013·Journal of Drug Targeting·Lin ZhangJie Sun
Feb 3, 2012·Journal of Drug Targeting·Ana Grenha
Aug 1, 2014·Journal of Biomedical Science·Alireza TahamtanMishar Kelishadi
Feb 13, 2013·Carbohydrate Polymers·N GoodarziR Dinarvand
Aug 15, 2018·Journal of Drug Targeting·Sweet NaskarSuraj Sharma
Feb 24, 2018·Future Medicinal Chemistry·Arcadia Woods, Khondaker Miraz Rahman
Aug 11, 2017·The Journal of Biological Chemistry·Leo D BemenaHideki Nakanishi
Jun 23, 2020·Biomacromolecules·Christoph FedererAndreas Bernkop-Schnürch
Nov 17, 2020·International Journal of Pharmaceutics·Omar S Abu AbedAmal A Elkordy

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