Thiol/disulfide homeostasis as a marker of oxidative stress in rosacea: a controlled spectrophotometric study

Cutaneous and Ocular Toxicology
Sertac SenerAkin Aktas

Abstract

Rosacea is the chronic inflammatory disease of the facial skin. Although its aetiology is not clear yet, inflammatory processes triggered by oxidative stress and oxidation of lipids have been suggested to play a role. While studies on the relationship between inflammation and oxidative stress are ongoing, thiol metabolism and its role in oxidative stress have also begun to be investigated. Thiols are among the key molecules of protein metabolism in the organism and they are the firstly consumed antioxidants in case of oxidative stress. Thiols regulate intracellular redox metabolism and protect keratinocytes against the results of oxidative alterations in the stratum corneum. There is a balance known as dynamic thiol/disulfide homeostasis between thiols and their oxidized forms; disulfides. This study aimed to determine the effects of oxidative stress on protein metabolism in rosacea patients by investigating thiol/disulfide homeostasis using a newly developed and fully automated method. Determination of plasma thiol levels provides important clues regarding the extent of free radical-mediated oxidation of proteins causing damage in rosacea. The study included 50 rosacea patients who were diagnosed clinically or histopathologica...Continue Reading

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Citations

Sep 6, 2019·Journal of Cosmetic Dermatology·Murat Ozturk, Isa An
Aug 21, 2020·International Journal of Dermatology·Kayla M BabbushAmor Khachemoune
Apr 2, 2020·Journal of Cosmetic Dermatology·Dursun Turkmen
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Dec 31, 2020·Metabolites·Corina Daniela EneIlinca Nicolae
Feb 12, 2021·International Journal of Clinical Practice·Yusuf SebelHakim Celik
Jul 3, 2021·Journal of Clinical Medicine·Simona Roxana GeorgescuMircea Tampa
Feb 2, 2021·Acta Microbiologica Et Immunologica Hungarica·Marie Isolde JouraEszter Ostorházi
Sep 27, 2021·Journal of Cosmetic Dermatology·Suzan Demir PektasDuygu Yazgan Aksoy
Oct 16, 2021·Journal of Cosmetic Dermatology·Ayşe Akbaş, Fadime Kılınç

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