PMID: 11334695May 4, 2001Paper

Thiopental and phenytoin by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 minutes in dogs. An exploratory study

Resuscitation
W BehringerP Safar

Abstract

We are systematically exploring in our exsanguination cardiac arrest (CA) outcome model in dogs suspended animation (SA), i.e. immediate preservation of brain and heart for resuscitative surgery during CA, with delayed resuscitation. We have shown in dogs that inducing moderate cerebral hypothermia with an aortic arch flush of 500 ml normal saline solution of 4 degrees C, at start of CA 20 min no-flow, leads to normal functional outcome. We hypothesized that, using the same model, adding thiopental (or even better thiopental plus phenytoin) to the flush at ambient temperature (24 degrees C), which would be more readily available in the field, will also achieve normal functional outcome. Thirty dogs (20-28 kg) were exsanguinated over 5 min to CA of 20 min no-flow, and resuscitated by closed-chest cardiopulmonary bypass. They received assisted circulation to 2 h, 34 degrees C post-CA to 12 h, controlled ventilation to 20 h, and intensive care to 72 h. At CA 2 min, the dogs received an aortic arch flush of 500 ml saline at 24 degrees C by a balloon-tipped catheter, inserted through the femoral artery (control group 1, n=14). In group 2 (n=9), thiopental (variable total doses of 15-120 mg/kg) was added to the flush and given with r...Continue Reading

References

Dec 1, 1978·Anesthesiology·A L BleyaertG R Rao
May 1, 1979·Anesthesia and Analgesia·J P CullenF Romo-Salas
Sep 1, 1977·Stroke; a Journal of Cerebral Circulation·E M NemotoP Safar
Oct 26, 1992·Neuroscience Letters·P BonnekohK A Hossmann
May 1, 1991·Journal of Neurosurgery·J E BailesL Manack
Sep 1, 1990·Stroke; a Journal of Cerebral Circulation·H KinouchiM Motomiya
Jan 1, 1990·The American Journal of Emergency Medicine·P SafarS W Stezoski
Mar 27, 1989·Brain Research·W C TaftR J DeLorenzo
Feb 13, 1986·The New England Journal of Medicine·UNKNOWN Brain Resuscitation Clinical Trial I Study Group
Oct 1, 1988·Critical Care Medicine·B K Siesjö
Dec 1, 1986·Annals of Emergency Medicine·R F BellamyJ S Vayer
Dec 1, 1986·Annals of Emergency Medicine·C C Baker
Jul 1, 1985·Anesthesiology·A TurcantP Allain
Nov 1, 1973·Anesthesiology·J D Michenfelder, R A Theye
Jul 1, 1983·The Annals of Thoracic Surgery·J J LivesayD A Ott
Feb 1, 1984·Anesthesiology·S E GisvoldH Alexander
Sep 1, 1980·Stroke; a Journal of Cerebral Circulation·P Safar
Aug 1, 1982·Journal of Neurosurgery·L N SuttonD A Bruce
Apr 1, 1995·Journal of Neurotrauma·S ImaizumiT Yoshimoto
Jul 1, 1994·Journal of Neurosurgical Anesthesiology·E M NemotoJ M Darby
Jan 1, 1994·The Journal of Trauma·G J OrdogW Shoemaker
Jun 1, 1993·The Annals of Thoracic Surgery·A M GillinovW A Baumgartner
Dec 2, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·W BehringerS A Tisherman
Aug 9, 2001·The Journal of Trauma·J W JohnsonM F Rotondo

❮ Previous
Next ❯

Citations

Dec 24, 2004·Der Anaesthesist·E PoppB W Böttiger
Apr 10, 2002·Critical Care Medicine·Peter SafarFritz Sterz
Mar 27, 2004·Critical Care Medicine·Samuel A Tisherman
Dec 20, 2007·The Neurologist·Demetris YannopoulosKeith G Lurie
Feb 18, 2010·Reviews in the Neurosciences·Calixto Machado, Julius Korein
Oct 5, 2006·Current Opinion in Anaesthesiology·Peter J Safar, Samuel A Tisherman
Jul 30, 2003·European Journal of Anaesthesiology·C L Gwinnutt, J P Nolan
Jan 3, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Calixto MachadoGerry Leisman
Jul 12, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xianren WuPatrick M Kochanek
Jul 13, 2004·Experimental Neurology·L HoyteA M Buchan
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wilhelm BehringerSamuel A Tisherman
May 26, 2017·The Journal of Trauma and Acute Care Surgery·Samuel A TishermanPatrick M Kochanek
Nov 19, 2017·ANZ Journal of Surgery·Syed MohiyaddinSaeed Ashraf
Aug 31, 2017·Journal of the Royal Army Medical Corps·Samuel Tisherman, J O'Connor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.