Thiopentone and propofol, but not methohexitone nor midazolam, inhibit neutrophil oxidative responses to the bacterial peptide FMLP

European Journal of Anaesthesiology
Dieter FröhlichKai Taeger

Abstract

The effects of different anaesthetics on the neutrophil oxidative response in vitro are compared. Neutrophils were stimulated with small amounts of the bacterial peptide N-formyl-L-methionyl-L-leucyl-phenylalanine as a physiological, receptor-dependent stimulus. A new flow cytometry-based method capable of detecting the small amounts of H2O2 generated by neutrophils in a heterogeneous all-or-none response following submaximal stimulation with N-formyl-L-methionyl-L-leucyl-phenylalanine was used. Propofol and thiopentone suppressed the respiratory burst significantly (P < 0.05 and P < 0.01) in therapeutic concentrations, while midazolam and methohexitone inhibited significantly (P < 0.01) only at concentrations greater than the therapeutic range. Impairment of the neutrophil response was primarily because of a reduction in the number of neutrophils participating in the respiratory burst and not of a proportional decrease of the fluorescence of all neutrophils.

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Citations

Mar 22, 2002·British Journal of Pharmacology·Sigrid WittmannStephen Daniels
Jan 12, 1999·Mediators of Inflammation·M Mathy-HartertM Lamy
Dec 8, 2005·International Immunopharmacology·Sigrid WittmannStephen Daniels
Mar 23, 2017·Critical Care : the Official Journal of the Critical Care Forum·Fernanda Ferreira CruzPaolo Pelosi
Aug 23, 2017·World Journal of Critical Care Medicine·Luciana Boavista Barros HeilPatricia Rieken Macedo Rocco
Jul 13, 2002·European Journal of Anaesthesiology·D FröhlichK Taeger
Jun 25, 2009·Journal of Cardiac Surgery·Efstratios ApostolakisDimitris Dougenis
Jul 12, 2007·The Journal of Trauma·Izabela Pagowska-KlimekHenryk Tchórzewski

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