Thiopurine Therapy for Inflammatory Bowel Disease During Pregnancy Is Not Associated with Anemia in the Infant

Digestive Diseases and Sciences
Benjamin KoslowskyAriella Bar-Gil Shitrit

Abstract

Thiopurine exposure throughout pregnancy in patients with inflammatory bowel diseases (IBD) is common and teratogenically safe. Late consequences of in utero exposure to thiopurines and its metabolite, 6-thioguanine nucleotides (6-TGN), such as neonatal and infant anemia are still disputed. To evaluate whether 6-TGN exposure during pregnancy influences anemia in infants at 1 year of life. A comparative observational study was performed between 2009 and 2015 at a multidisciplinary IBD clinic dedicated to pregnant women. The hemoglobin level and signs of anemia between 9 and 15 months after birth of infants born to women exposed to thiopurines throughout the entire pregnancy was compared to infants of women with no thiopurine exposure during pregnancy. Altogether, 34 patients, 21 in the study group and 13 in the control group, were included. The median duration of maternal thiopurine exposure prior to pregnancy was 24 months (range 12-72 months), and median dosage was 100 mg (range 50-175 mg). Maternal IBD activity, infants' iron supplementation, and iron deficiency diagnoses were similar between both groups. The infants' mean hemoglobin level (gr/dL) in the thiopurine-exposed women versus the control group was 11.48 ± 0.8 versus...Continue Reading

References

Sep 3, 2008·Alimentary Pharmacology & Therapeutics·L A ChristensenK Schmiegelow
Apr 2, 2011·Journal of Crohn's & Colitis·Sieglinde AngelbergerClemens Dejaco
Jul 31, 2013·Nature Reviews. Gastroenterology & Hepatology·Ole Haagen NielsenJakob Hendel
Oct 8, 2015·Inflammatory Bowel Diseases·Ryan A McConnell, Uma Mahadevan
Dec 22, 2015·Gastroenterology·Geoffrey C NguyenUNKNOWN Canadian Association of Gastroenterology
Apr 14, 2016·Digestive Diseases and Sciences·Ariella Bar-Gil ShitritEran Goldin

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Citations

Jan 8, 2021·Expert Opinion on Drug Safety·Robyn LaubeRupert W Leong
Jun 11, 2021·Alimentary Pharmacology & Therapeutics·Roni WeisshofDaniel Kurnik

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