Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia

Biochimica Et Biophysica Acta
Juan Ignacio RomeroFrancisco Capani

Abstract

Thioredoxin (Trx) family proteins are crucial mediators of cell functions via regulation of the thiol redox state of various key proteins and the levels of the intracellular second messenger hydrogen peroxide. Their expression, localization and functions are altered in various pathologies. Here, we have analyzed the impact of Trx family proteins in neuronal development and recovery, following hypoxia/ischemia and reperfusion. We have analyzed the regulation and potential functions of Trx family proteins during hypoxia/ischemia and reoxygenation of the developing brain in both an animal and a cellular model of perinatal asphyxia. We have analyzed the distribution of 14 Trx family and related proteins in the cerebellum, striatum, and hippocampus, three areas of the rat brain that are especially susceptible to hypoxia. Using SH-SY5Y cells subjected to hypoxia and reoxygenation, we have analyzed the functions of some redoxins suggested by the animal experiment. We have described/discovered a complex, cell-type and tissue-specific expression pattern following the hypoxia/ischemia and reoxygenation. Particularly, Grx2 and Trx1 showed distinct changes during tissue recovery following hypoxia/ischemia and reoxygenation. Silencing of th...Continue Reading

References

Sep 1, 1978·Stroke; a Journal of Cerebral Circulation·E S FlammJ Ransohoff
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P N HoffmanD L Price
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley
Mar 15, 1995·Structure·J L Martin
Mar 1, 1994·Progress in Neurobiology·J W Phillis
Dec 1, 1996·Neuropathology and Applied Neurobiology·A D Edwards, H Mehmet
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K HirotaJ Yodoi
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y TakagiJ Yodoi
Sep 10, 1998·American Journal of Obstetrics and Gynecology·K B Nelson, J K Grether
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y TakagiJ Yodoi
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Oct 30, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C FanJ F Engelhardt
Dec 10, 1999·The Journal of Biological Chemistry·M UenoT Nikaido
Sep 30, 2000·European Journal of Biochemistry·E S Arnér, A Holmgren
Mar 29, 2001·Biology of the Neonate·G BuonocoreR Bracci
Jun 1, 2001·Pediatric Research·M V JohnstonW Nakajima
Jan 25, 2002·IUBMB Life·S G RheeK Kim
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andre KuliszPaul T Schumacker
May 30, 2002·Biological Chemistry·Birgit HofmannLeopold Flohé
Nov 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thorsten MengesdorfWulf Paschen
Jan 9, 2003·Trends in Biochemical Sciences·Zachary A WoodLeslie B Poole
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre, Joel M Weinberg
Dec 20, 2003·Cell Death and Differentiation·S Oyadomari, M Mori
Aug 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher Horst LilligArne Holmgren
Oct 27, 2004·Early Human Development·Lina Shalak, Jeffrey M Perlman
Jan 15, 2005·Biochemical and Biophysical Research Communications·Mari EnokssonSten Orrenius
Jan 26, 2005·American Journal of Nephrology·E Nigel Wardle
May 14, 2005·Antioxidants & Redox Signaling·Hajime Nakamura
Jul 28, 2005·Developmental Neuroscience·Robert C Vannucci, Susan J Vannucci
Feb 24, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·A D Edwards, D V Azzopardi
Nov 23, 2006·Antioxidants & Redox Signaling·Christopher Horst Lillig, Arne Holmgren
Jul 16, 2008·Biochimica Et Biophysica Acta·Christopher Horst LilligArne Holmgren
Jul 19, 2008·Anesthesia and Analgesia·Michael P HutchensPer O Jarnberg
Nov 8, 2008·Journal of Visualized Experiments : JoVE·Kin ChiuRaymond Chuen-Chung Chang
Dec 11, 2008·Journal of Visualized Experiments : JoVE·Hidetoshi Taniguchi, Katrin Andreasson

❮ Previous
Next ❯

Citations

Jul 26, 2016·Frontiers in Aging Neuroscience·Tamara LogicaFrancisco Capani
Jul 15, 2017·Oxidative Medicine and Cellular Longevity·Juan Ignacio RomeroFrancisco Capani
Mar 25, 2018·Translational Stroke Research·Ye LiuDavid W Howells
Dec 26, 2018·Oxidative Medicine and Cellular Longevity·Claudia UrbainskyChristopher Horst Lillig
Mar 23, 2017·Neural Plasticity·María Inés HerreraFrancisco Capani
Jan 24, 2020·Frontiers in Neuroscience·Lucas D UdovinFrancisco Capani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Biochemical Society Transactions
Arne HolmgrenChristopher Horst Lillig
Proceedings of the National Academy of Sciences of the United States of America
Y TakagiJunji Yodoi
© 2022 Meta ULC. All rights reserved