Thioredoxin expression in the human endometrium during the menstrual cycle

Molecular Human Reproduction
T MaruyamaJ Yodoi

Abstract

Human thioredoxin, a cellular disulphide reducing protein, is known to be secreted by some types of cells and to display unique extracellular activities including modulation of cytokine actions and protection of the cell against damage from oxidative stress. This study has been undertaken to investigate the pattern of expression and tissue distribution of thioredoxin in human endometrium during the menstrual cycle. Immunohistochemical studies showed increased thioredoxin immunoreactivity in the glands of the secretory phase compared to those of the proliferative phase. Although the staining of thioredoxin was relatively intense in predecidual stromal cells, the most prominent staining of thioredoxin was present in both glands and stroma of the endometrium in the early secretory phase of the menstrual cycle. Northern hybridization analyses revealed that expression of thioredoxin mRNA in the endometrium of the early secretory phase was approximately 3-fold compared to the other phases of the menstrual cycle, consistent with the results of the immunohistochemical studies. These results suggest that both protein and gene expression of thioredoxin in the endometrium are menstrual cycle phase-specific and highly active in the phase o...Continue Reading

Citations

Mar 10, 2001·Molecular Reproduction and Development·L J OsborneF M Clarke
Apr 18, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·J M Stark
May 7, 2003·The Journal of Steroid Biochemistry and Molecular Biology·C PunyadeeraP Groothuis
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Mar 7, 2001·Antioxidants & Redox Signaling·N NodaH Wakasugi
Sep 22, 2006·Antioxidants & Redox Signaling·Norihiko KondoJunji Yodoi
Nov 23, 2006·Antioxidants & Redox Signaling·Christopher Horst Lillig, Arne Holmgren
Feb 23, 2010·Human Reproduction·Seok Kyo SeoByung Seok Lee
Jun 21, 2002·Annals of the New York Academy of Sciences·Kiichi HirotaJunji Yodoi
Jun 27, 2008·Endocrine Journal·Tetsuo Maruyama, Yasunori Yoshimura
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