Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide

ELife
Yingsong HaoJoshua M Kaplan

Abstract

Nitric oxide (NO) is released into the air by NO-producing organisms; however, it is unclear if animals utilize NO as a sensory cue. We show that C. elegans avoids Pseudomonas aeruginosa (PA14) in part by detecting PA14-produced NO. PA14 mutants deficient for NO production fail to elicit avoidance and NO donors repel worms. PA14 and NO avoidance are mediated by a chemosensory neuron (ASJ) and these responses require receptor guanylate cyclases and cyclic nucleotide gated ion channels. ASJ exhibits calcium increases at both the onset and removal of NO. These NO-evoked ON and OFF calcium transients are affected by a redox sensing protein, TRX-1/thioredoxin. TRX-1's trans-nitrosylation activity inhibits the ON transient whereas TRX-1's de-nitrosylation activity promotes the OFF transient. Thus, C. elegans exploits bacterially produced NO as a cue to mediate avoidance and TRX-1 endows ASJ with a bi-phasic response to NO exposure.

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Citations

Dec 28, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ryuichi SaitoMotomichi Doi
Aug 13, 2020·Journal of Neurogenetics·Dennis H Kim, Steven W Flavell
Nov 8, 2020·Communications Biology·Nicole L Stuhr, Sean P Curran
Oct 16, 2020·Journal of Neurogenetics·He Liu, Yun Zhang
Mar 12, 2021·Genetics·Denise M FerkeyNoelle D L'Etoile
Oct 15, 2020·Trends in Neurosciences·Ambra MasuzzoJulien Royet
Aug 10, 2021·Current Research in Immunology·Phillip Wibisono, Jingru Sun
Feb 1, 2022·PLoS Genetics·Wenxing YangYun Zhang

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Methods Mentioned

BETA
Fluorescence

Software Mentioned

Metamorph
SPSS Statistics
Fiji

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