PMID: 5909783Mar 4, 1966

Thiosemicarbazide injection followed by electric shock increases resistance to stress in rats

Science
R W Reynolds, M R Meeker

Abstract

Adult rats that had been raised with a minimum of stimulation were injected with thiosemicarbazide, a drug that lowers y-aminobutyric acid concentrations. Fifteen minutes later the animals were given 30 mild electric shocks over a half-hour period. Two. weeks later they were tested for their resistance to gastric ulceration induced by immobilization. The experimental animals showed a much greater resistance to stress than did the appropriate control groups. A replication confirmed the results of the first study.

Citations

Jun 1, 1978·Bulletin of Environmental Contamination and Toxicology·J L BurlesonW H Glaze
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·W P Paré, G B Glavin

Related Concepts

Aminobutyrates
Electric Stimulation Technique
Electroconvulsive Shock
Hypokinesia, Experimental
Semicarbazides
Gastric Ulcer

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