Third-generation cryotherapy for prostate cancer in the UK: a prospective study of the early outcomes in primary and recurrent disease

BJU International
Joanne CresswellDamian Greene

Abstract

To present the early results of the use of third-generation cryotherapy in primary and recurrent prostate cancer at one UK centre. Over a 14-month period 51 patients underwent cryotherapy for prostate cancer. In 31 patients cryotherapy was used as the primary treatment and in 20 as a salvage treatment after radiotherapy or hormone ablation. Data were collected prospectively and the median follow-up was 9 months. The prostate-specific antigen (PSA) level decreased to <0.5 ng/mL in 79% of patients undergoing primary treatment and in 67% of patients undergoing salvage treatment. A higher Gleason grade and PSA levels were associated with a poorer outcome. No patient developed a fistula, 4% developed urinary retention requiring transurethral prostatectomy and 4% had persistent incontinence. The rates of erectile dysfunction were high (86%). The median inpatient stay was 2 days. Early results suggest that cryotherapy offers a safe alternative for primary and recurrent prostate cancer, particularly for older and less fit patients. Long-term data are required to assess the durability of response and the effect on survival.

References

Dec 1, 1972·The Journal of Urology·R H FlocksD L Boatman
Jun 1, 1994·Cryobiology·J K Cohen, R J Miller
Nov 20, 1997·The Journal of Urology·K ShinoharaP R Carroll
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A K LeventisK M Slawin
Mar 31, 2004·BJU International·J ReesR Persad
Mar 5, 2005·Cancer·Kristofer L PrepelicaAaron E Katz
May 12, 2005·Urologic Oncology·Dan LeiboviciYoram I Siegel
May 17, 2005·BJU International·John G Baust, Andrew A Gage

❮ Previous
Next ❯

Citations

Apr 18, 2009·Current Urology Reports·Chad R Ritch, Aaron E Katz
May 7, 2010·Journal of Endourology·Vladimir MouravievThomas J Polascik
Jun 10, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-F HétetP Hallouin
Jun 21, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Rowland Illing, Alexander Chapman
Mar 17, 2012·European Urology·Vladimir MouravievJ Stephen Jones
Sep 10, 2010·Urologic Oncology·Jorge R CasoThomas J Polascik
Sep 27, 2008·The Journal of Urology·Richard J BabaianJ Brantley Thrasher
Sep 16, 2008·European Urology·Johan F LangenhuijsenHenk Vergunst
Jan 13, 2011·BJU International·Carvell T Nguyen, J Stephen Jones
Jul 9, 2009·BJU International·Masaki KimuraThomas J Polascik
Jan 31, 2012·Urologia Internationalis·Prodromos PhilippouFrancis Chinegwundoh
Nov 8, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Fernando J KimWilson R Molina
Jul 22, 2017·Technology in Cancer Research & Treatment·Purva JoshiYoed Rabin
Feb 6, 2018·International Journal of Computer Assisted Radiology and Surgery·Purva JoshiYoed Rabin
Oct 15, 2013·Urologia·Maria Angela CerrutoWalter Artibani
Feb 4, 2009·Current Opinion in Urology·Thomas J PolascikVladimir Mouraviev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.