Apr 13, 2016

Third-generation sequencing and the future of genomics

BioRxiv : the Preprint Server for Biology
Hayan LeeMichael C Schatz

Abstract

Third-generation long-range DNA sequencing and mapping technologies are creating a renaissance in high-quality genome sequencing. Unlike second-generation sequencing, which produces short reads a few hundred base-pairs long, third-generation single-molecule technologies generate over 10,000 bp reads or map over 100,000 bp molecules. We analyze how increased read lengths can be used to address long-standing problems in de novo genome assembly, structural variation analysis and haplotype phasing.

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Mentioned in this Paper

Genome
Genome Assembly Sequence
Human DNA Sequencing
Genomics
Sequencing
Massively-Parallel Sequencing
Sequence Determinations, DNA
Structure
Analysis
Genome Sequencing

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