PMID: 2123313Oct 1, 1990Paper

Third place--Resident Clinical Science Award 1990. The in vivo and in vitro effect of phenylephrine (Neo Synephrine) on nasal ciliary beat frequency and mucociliary transport

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
P P PhillipsE B Kern

Abstract

Twenty volunteers with normal noses were studied to determine the effect of phenylephrine on nasal ciliary function. In vivo study of this drug was performed in 15 patients and revealed a significant increase in their ciliary beat frequency from a control of 11 Hz to 12.03 Hz (p = 0.001). Mucociliary transit times in these volunteers were also studied, revealing a mean of 9.9 minutes prestimulation and 10.2 minutes poststimulation, which was not statistically significant (p = 0.77). Five additional subjects donated ciliated mucosal samples for in vitro analysis of varying concentrations of this agent that showed a significant ciliostimulatory effect at lower concentrations (0.01%), with a progressive cilioinhibitory effect at higher concentrations (0.25%, 0.5%). The 0.05% concentration showed no significant change in ciliary activity compared to control measurements. These data demonstrate that phenylephrine has a ciliostimulatory effect in vivo, as well as in appropriate concentrations in vitro, and should be safe and relatively nontoxic to the mucociliary apparatus for short-term use.

References

Apr 1, 1988·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J L FergusonW J Martin
Jul 1, 1985·International Journal of Pediatric Otorhinolaryngology·D Passàli, M Bianchini Ciampoli
Mar 1, 1981·Acta Oto-laryngologica·E PuchelleA Bertrand
Jan 27, 1984·European Journal of Pharmacology·I Maruyama
Jul 1, 1982·Acta Oto-laryngologica·J C Hybbinette, U Mercke

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Citations

Oct 1, 1993·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·F R AmbleT Runer
Apr 15, 2008·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Luo ZhangZhongyan Liu
Dec 17, 2014·American Journal of Rhinology & Allergy·Alan D Workman, Noam A Cohen
Oct 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M L HinniJ L Kasperbauer
Mar 11, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hiroko IidaKazuhiko Fukuda
Mar 27, 2019·Allergy, Asthma & Immunology Research·Jian Jiao, Luo Zhang
Feb 1, 1994·Respiratory Medicine·C RusznakR J Davies

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