Third-window vibroplasty with an active middle ear implant: assessment of physiologic responses in a model of stapes fixation in Chinchilla lanigera

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
J Eric LupoDaniel J Tollin

Abstract

Mechanical stimulation through a cochlear third window into the scala tympani in a chinchilla model with normal and fixed stapes can generate cochlear responses equivalent to acoustic stimuli. Cochlear stimulation via the round window (RW) using active middle ear implants (AMEIs) can produce physiologic responses similar to acoustic stimulation including in a model of stapes fixation. However, pathologic conditions, such as advanced otosclerosis, can preclude delivery of sound energy to the cochlea through the oval window and/or the RW. Cochlear microphonic (CM) and laser Doppler vibrometer measurements of stapes and RW velocities were performed in 6 ears of 4 chinchillas. Baseline measurements to acoustic sinusoidal stimuli (0.25-8 kHz) were made. Measurements were repeated with an AMEI driving the RW or a third window to the scala tympani before and after stapes fixation. AMEI stimulation of the third window produced CM waveforms with morphologies similar to acoustic stimuli. CM thresholds with RW and third-window stimulation were frequency dependent but ranged from 0.25 to 10 and 0.5 to 40 mV, respectively. Stapes fixation, confirmed by laser Doppler vibrometer measurements, resulted in a significant frequency dependent impa...Continue Reading

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Citations

Feb 7, 2014·Journal of the Royal Society, Interface·Thomas D WeddellAndrei N Lukashkin
Apr 6, 2013·The Journal of the Acoustical Society of America·Michael E Ravicz, John J Rosowski
Oct 11, 2014·Otolaryngologic Clinics of North America·Herman A Jenkins, Kristin Uhler
Dec 5, 2019·The Journal of the Acoustical Society of America·Monica TrevinoMichael G Heinz
Dec 18, 2013·The Laryngoscope·Erich VyskocilWolfgang Gstoettner

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