PMID: 16538040Mar 16, 2006Paper

Thirteen-week oral toxicity of para- and ortho- chloronitrobenzene in rats and mice

The Journal of Toxicological Sciences
Michiharu MatsumotoTaijiro Matsushima

Abstract

Para- and ortho-chloronitrobenzene (p- and o-CNB) were compared for subchronic toxicity by feeding F344 rats and BDF(1) mice of both sexes p-CNB-or o-CNB-containing diets at 5 different concentrations for 13 weeks. The two isomers induced hematotoxicity and hepatotoxicity of different toxic potencies. p-CNB produced an anemic sign of external appearance in rats and mice, while o-CNB did not. Significant increases in the incidences of increased erythropoiesis in the bone marrow and increased extramedullary hematopoiesis in the spleen and liver, and in serum total bilirubin in rats and mice appeared at lower dose levels of p-CNB than o-CNB. A significant increase in serum ALT activity appeared at lower dose levels of o-CNB than p-CNB, together with appearance of both necrosis and hydropic degeneration of hepatocytes only in the o-CNB-fed rats and nuclear enlargement with atypia of hepatocytes only in the o-CNB-fed mice. BMDL(10)s of p- and o-CNB for the hematotoxic endpoint, substitutes for NOAELs, were 0.177 mg/kg/day and 1.03 mg/kg/day for the rats, respectively. For the mice, the NOAELs of p-and o-CNB for the hematotoxic endpoint were 10.5 mg/kg/day and 10.4 mg/kg/day, respectively. A NOEL of o-CNB for the hepatotoxic endpoint...Continue Reading

References

Jul 5, 1976·International Archives of Occupational and Environmental Health·T WatanabeM Ikeda
Jan 1, 1991·Archives of Toxicology·T YoshidaT Tabuchi
May 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R S NairJ B Terrill
Nov 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R S NairJ B Terrill
Nov 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B C AllenE M Faustman
Mar 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G S TravlosJ R Bucher
Sep 1, 1956·The Biochemical Journal·H G BRAYW V THORPE
Dec 17, 2003·Journal of Occupational Health·Hideki SenohTaijiro Matsushima

❮ Previous
Next ❯

Citations

Apr 25, 2009·Journal of Occupational Health·Kazunori YamazakiShoji Fukushima
Sep 9, 2006·The Journal of Toxicological Sciences·Michiharu MatsumotoTaijiro Matsushima
Jan 14, 2011·Toxicologic Pathology·Bob ThoolenJerrold M Ward
Jan 14, 2012·Human & Experimental Toxicology·A P Firdous, Ramadasan Kuttan
Oct 20, 2012·International Journal of Radiation Biology·Alikkunjhi P FirdousRamadasan Kuttan
Aug 6, 2013·Nutrition and Cancer·Alikkunjhi Pararikkal FirdousRamadasan Kuttan
Sep 22, 2017·Chemical Research in Toxicology·Gabriele Sabbioni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Related Papers

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Michiharu MatsumotoTaijiro Matsushima
Journal of Occupational Health
Shigetoshi AisoTaijiro Matsushima
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences
M MiyauchiM Hirose
© 2021 Meta ULC. All rights reserved