PMID: 11932165Apr 5, 2002Paper

Thirteen years follow-up after radical transsternal thymectomy for myasthenia gravis. Do short-term results predict long-term outcome?

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Thierry Christophe RothRalph Alexander Schmid

Abstract

Long-term evaluation of efficacy and quality of life after radical surgical approach for myasthenia gravis (MG). Comparison between short-term follow-up and long-term outcome. All patients (n=26, 16 men and 10 women, mean age: 40.7 years) underwent total transsternal thymectomy for MG between 1986 and 1989. Prospective analysis of the patients for short-term follow-up (mean 22.4 months) was published in 1991. The same group of patients was reevaluated in 2001 (range of follow-up 11.4-15.2 years) and assessed according to the classification of Osserman and Oosterhuis. Mean follow-up was 13.0 years (range 11.4-15.2 years). Two patients were lost from follow-up and one died 4 years after thymectomy for reasons unrelated to MG (n=23). No early or late postoperative mortality was observed. One sternal osteomyelitis occurred. Late postoperative morbidity included sternal instabilities (n=2), mild residual thoracic pain (n=6), and hypertrophic scars (n=7). Five patients were rehospitalized for aggravating MG and needed plasmapheresis (n=3) and intubation (n=1). Thirteen patients (56.5%) showed objective clinical improvement, including six patients (26.1%) with complete remission. Eleven patients (47.8%) do not take any medication at a...Continue Reading

Citations

Mar 28, 2008·Surgery Today·Marco AlifanoMaurizio Boaron
Jul 31, 2013·Neurocritical Care·Axel Petzold, Armand Girbes
Sep 2, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·José M PonsetiManuel Armengol
May 27, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·I O OnwuekweC Onyejizu
Jun 24, 2008·Annals of the New York Academy of Sciences·Joshua R Sonett, Alfred Jaretzki
Oct 24, 2012·Journal of Clinical Neurology·Zhi-Feng MaoMaree L Hackett
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May 29, 2008·Expert Review of Neurotherapeutics·Simone FerreroNicola Ragni
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Feb 25, 2020·Interactive Cardiovascular and Thoracic Surgery·Juha KauppiJari Räsänen
Jan 24, 2017·The New England Journal of Medicine·Joseph B Shrager
Mar 12, 2019·Therapeutic Advances in Neurological Disorders·Christiane Schneider-GoldTobias Ruck

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