PMID: 8944445Oct 1, 1996Paper

Thirty-five years of isolated limb perfusion for melanoma: indications and results

The British Journal of Surgery
Bart C VrouenraetsB B Kroon

Abstract

Isolated limb perfusion (ILP) for limb melanoma remains controversial despite its frequent use for over 35 years. To determine whether it has proven benefits, reported results have been reviewed. The value of adjuvant ILP cannot be determined from the multitude of retrospective studies on this subject. Preliminary results of the large European Organization for Research and Treatment of Cancer-World Health Organization-North American Perfusion Group trial suggest that patients with melanomas of 1.5-3.0 mm in thickness who do not undergo elective lymph node dissection may have a locoregional control benefit from ILP. However, as long as a definite survival advantage for ILP has not been demonstrated, such treatment does not seem justified for these patients. The value of prophylactic ILP after resection of recurrent limb melanoma is also scientifically unproven. The potential prevention of further limb recurrence for only a limited period of time, as demonstrated in a rather small Swedish trial, probably does not justify routine use of ILP in these patients; a large international trial will be needed to assess whether ILP provides a survival advantage. For those with locally inoperable limb melanoma, ILP appears to be the treatme...Continue Reading

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Citations

Apr 21, 1998·Seminars in Surgical Oncology·B C VrouenraetsB B Kroon
Apr 21, 1998·Seminars in Surgical Oncology·J F ThompsonC R Harman
Mar 29, 2002·Journal of Surgical Oncology·Bin B R KroonOmgo E Nieweg
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