This is what COPD looks like

Respirology : Official Journal of the Asian Pacific Society of Respirology
Khadija SheikhGrace Parraga

Abstract

Despite decades of research, and the growing healthcare and societal burden of chronic obstructive pulmonary disease (COPD), therapeutic COPD breakthroughs have not occurred. Sub-optimal COPD patient phenotyping, an incomplete understanding of COPD pathogenesis and a scarcity of sensitive tools that provide patient-relevant intermediate endpoints likely all play a role in the lack of new, efficacious COPD interventions. In other words, COPD patients are still diagnosed based on the presence of persistent airflow limitation measured using spirometry. Spirometry measurements reflect the global sum of all the different possible COPD pathologies and perhaps because of this, we lose sight of the different contributions of airway and parenchymal abnormalities. With recent advances in thoracic X-ray computed tomography (CT) and magnetic resonance imaging (MRI), lung structure and function abnormalities may be regionally identified and measured. These imaging endpoints may serve as biomarkers of COPD that can be used to better phenotype patients. Therefore, here we review novel CT and MRI measurements that help reveal COPD phenotypes and what COPD really 'looks' like, beyond spirometric indices. We discuss MR and CT imaging approaches ...Continue Reading

References

Jul 1, 1978·AJR. American Journal of Roentgenology·G N Hounsfield
Apr 1, 1971·Seminars in Nuclear Medicine·J Milic-Emili
Sep 1, 1970·Human Pathology·R S MitchellJ C Maisel
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·P A GevenoisJ C Yernault
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M OkazawaP D Paré
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·H O CoxsonJ C Hogg
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·M MishimaB Suki
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·Y NakanoM Mishima
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dmitriy A YablonskiyMark S Conradi
Feb 18, 2003·Respiratory Medicine·B LundbäckUNKNOWN Obstructive Lung Disease in Northern Sweden Studies
Jun 25, 2004·The New England Journal of Medicine·James C HoggPeter D Paré
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Yasutaka NakanoPeter D Paré
Aug 9, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard E JacobMark S Conradi
Oct 29, 2005·Academic Radiology·Sean B FainJohn Owers-Bradley
Dec 16, 2005·IEEE Transactions on Medical Imaging·Juerg TschirrenMilan Sonka
Feb 10, 2006·Physics in Medicine and Biology·Thomas GuerreroRitsuko Komaki
Apr 13, 2006·IEEE Transactions on Medical Imaging·Ye XuEric A Hoffman
Oct 24, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jason C WoodsJames C Hogg
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan DriehuysG Allan Johnson
Mar 17, 2007·COPD·Julia Ley-ZaporozhanHans-Ulrich Kauczor
Aug 3, 2007·Respiration; International Review of Thoracic Diseases·Alice M Wood, Robert A Stockley
Sep 4, 2007·Lancet·David M Mannino, A Sonia Buist
Nov 27, 2007·Journal of Magnetic Resonance·A L Sukstanskii, D A Yablonskiy
Dec 22, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alfred StadlerAlexander A Bankier
Jan 25, 2008·The European Respiratory Journal·J VestboUNKNOWN ECLIPSE investigators
May 6, 2008·Seminars in Cancer Biology·Jennifer S FangRobert A Gatenby
Aug 9, 2008·International Journal of Chronic Obstructive Pulmonary Disease·Masashi TakahashiKiyoshi Murata
Jul 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Grzegorz BaumanLothar R Schad
Nov 21, 2009·American Journal of Respiratory and Critical Care Medicine·Thomas B GrydelandPer S Bakke
Feb 5, 2010·IEEE Transactions on Medical Imaging·Lauge SørensenMarleen de Bruijne
Mar 11, 2010·COPD·Elizabeth A ReganJames D Crapo
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sara K AlfordEric A Hoffman
Aug 3, 2010·Journal of Magnetic Resonance Imaging : JMRI·Masaya TakahashiIvan Dimitrov
Mar 12, 2011·Academic Radiology·Hester A GietemaUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
Mar 18, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Sivaram KaushikBastiaan Driehuys

❮ Previous
Next ❯

Citations

Oct 7, 2016·European Journal of Radiology·Lukas EbnerSean B Fain
May 28, 2016·The European Respiratory Journal·Kristoffer Ostridge, Tom M A Wilkinson
Apr 4, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tow Keang LimJudith Mak
Mar 28, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Don D Sin, Gregory G King
Dec 3, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Min LiJun-Feng Du
Oct 30, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Marlies van DijkDirk-Jan Slebos
Apr 21, 2021·The British Journal of Radiology·Joshua R AstleyBilal A Tahir

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Harvey O CoxsonDon Sin
Journal of Magnetic Resonance Imaging : JMRI
Julia Ley-Zaporozhan, Edwin J R van Beek
© 2021 Meta ULC. All rights reserved